Cellular blebs: pressure-driven, axisymmetric, membrane protrusions
AuthorsWoolley, Thomas E.
Gaffney, Eamonn A.
Oliver, James M.
Baker, Ruth E.
Waters, Sarah L.
KAUST Grant NumberKUK-C1-013-04
Online Publication Date2013-07-16
Print Publication Date2014-04
Permanent link to this recordhttp://hdl.handle.net/10754/597744
MetadataShow full item record
AbstractBlebs are cellular protrusions that are used by cells for multiple purposes including locomotion. A mechanical model for the problem of pressure-driven blebs based on force and moment balances of an axisymmetric shell model is proposed. The formation of a bleb is initiated by weakening the shell over a small region, and the deformation of the cellular membrane from the cortex is obtained during inflation. However, simply weakening the shell leads to an area increase of more than 4 %, which is physically unrealistic. Thus, the model is extended to include a reconfiguration process that allows large blebs to form with small increases in area. It is observed that both geometric and biomechanical constraints are important in this process. In particular, it is shown that although blebs are driven by a pressure difference across the cellular membrane, it is not the limiting factor in determining bleb size. © 2013 Springer-Verlag Berlin Heidelberg.
CitationWoolley TE, Gaffney EA, Oliver JM, Baker RE, Waters SL, et al. (2013) Cellular blebs: pressure-driven, axisymmetric, membrane protrusions. Biomech Model Mechanobiol 13: 463–476. Available: http://dx.doi.org/10.1007/s10237-013-0509-9.
SponsorsThis publication is based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). AG is a Wolfson Royal Society Merit Holder and acknowledges support from a Reintegration Grant under EC Framework VII.
CollectionsPublications Acknowledging KAUST Support
- Global contraction or local growth, bleb shape depends on more than just cell structure.
- Authors: Woolley TE, Gaffney EA, Oliver JM, Waters SL, Baker RE, Goriely A
- Issue date: 2015 Sep 7
- Cell Surface Mechanochemistry and the Determinants of Bleb Formation, Healing, and Travel Velocity.
- Authors: Manakova K, Yan H, Lowengrub J, Allard J
- Issue date: 2016 Apr 12
- Intracellular Pressure Dynamics in Blebbing Cells.
- Authors: Strychalski W, Guy RD
- Issue date: 2016 Mar 8
- Membrane shrinkage and cortex remodelling are predicted to work in harmony to retract blebs.
- Authors: Woolley TE, Gaffney EA, Goriely A
- Issue date: 2015 Jul
- Life and times of a cellular bleb.
- Authors: Charras GT, Coughlin M, Mitchison TJ, Mahadevan L
- Issue date: 2008 Mar 1