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    Cellular blebs: pressure-driven, axisymmetric, membrane protrusions

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    Type
    Article
    Authors
    Woolley, Thomas E.
    Gaffney, Eamonn A.
    Oliver, James M.
    Baker, Ruth E.
    Waters, Sarah L.
    Goriely, Alain cc
    KAUST Grant Number
    KUK-C1-013-04
    Date
    2013-07-16
    Online Publication Date
    2013-07-16
    Print Publication Date
    2014-04
    Permanent link to this record
    http://hdl.handle.net/10754/597744
    
    Metadata
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    Abstract
    Blebs are cellular protrusions that are used by cells for multiple purposes including locomotion. A mechanical model for the problem of pressure-driven blebs based on force and moment balances of an axisymmetric shell model is proposed. The formation of a bleb is initiated by weakening the shell over a small region, and the deformation of the cellular membrane from the cortex is obtained during inflation. However, simply weakening the shell leads to an area increase of more than 4 %, which is physically unrealistic. Thus, the model is extended to include a reconfiguration process that allows large blebs to form with small increases in area. It is observed that both geometric and biomechanical constraints are important in this process. In particular, it is shown that although blebs are driven by a pressure difference across the cellular membrane, it is not the limiting factor in determining bleb size. © 2013 Springer-Verlag Berlin Heidelberg.
    Citation
    Woolley TE, Gaffney EA, Oliver JM, Baker RE, Waters SL, et al. (2013) Cellular blebs: pressure-driven, axisymmetric, membrane protrusions. Biomech Model Mechanobiol 13: 463–476. Available: http://dx.doi.org/10.1007/s10237-013-0509-9.
    Sponsors
    This publication is based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). AG is a Wolfson Royal Society Merit Holder and acknowledges support from a Reintegration Grant under EC Framework VII.
    Publisher
    Springer Nature
    Journal
    Biomechanics and Modeling in Mechanobiology
    DOI
    10.1007/s10237-013-0509-9
    PubMed ID
    23857038
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10237-013-0509-9
    Scopus Count
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