Cardiac cell modelling: Observations from the heart of the cardiac physiome project

Fink, Martin; Niederer, Steven A.; Cherry, Elizabeth M.; Fenton, Flavio H.; Koivumäki, Jussi T.; Seemann, Gunnar; Thul, Rüdiger; Zhang, Henggui; Sachse, Frank B.; Beard, Dan; Crampin, Edmund J.; Smith, Nicolas P.

Type

Article

Authors

Fink, Martin
Niederer, Steven A.
Cherry, Elizabeth M.
Fenton, Flavio H.
Koivumäki, Jussi T.
Seemann, Gunnar
Thul, Rüdiger
Zhang, Henggui
Sachse, Frank B.
Beard, Dan
Crampin, Edmund J.
Smith, Nicolas P.

KAUST Grant Number

KUK-C1-013-04

Date

2011-01

Permanent link to this record

http://hdl.handle.net/10754/597735

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Abstract

In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field. © 2010 Elsevier Ltd.

Citation

Fink M, Niederer SA, Cherry EM, Fenton FH, Koivumäki JT, et al. (2011) Cardiac cell modelling: Observations from the heart of the cardiac physiome project. Progress in Biophysics and Molecular Biology 104: 2–21. Available: http://dx.doi.org/10.1016/j.pbiomolbio.2010.03.002.

Sponsors

This manuscript is the product of discussions at the Cardiac Physiome Program hosted at, and supported by, the Newton Institute Cambridge United Kingdom. NPS would like to acknowledge support from the United Kingdom Engineering and Physical Sciences Research Council (FP/F059361/1), Biotechnology and Biological Sciences Research Council (BB/F01080X/1) and the European Commission (FP7-ICT-2007-224495: euHeart). FBS acknowledges support by the Nora Eccles Treadwell Foundation. This publication is based on work (by EJC) supported in part by Award No KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). The authors also extend thanks to Liz Gresham for her proofreading of the manuscript.