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dc.contributor.authorSchiffman, Jessica D.
dc.contributor.authorWang, Yue
dc.contributor.authorGiannelis, Emmanuel P.
dc.contributor.authorElimelech, Menachem
dc.date.accessioned2016-02-25T12:44:08Z
dc.date.available2016-02-25T12:44:08Z
dc.date.issued2011-11
dc.identifier.citationSchiffman JD, Wang Y, Giannelis EP, Elimelech M (2011) Biocidal Activity of Plasma Modified Electrospun Polysulfone Mats Functionalized with Polyethyleneimine-Capped Silver Nanoparticles. Langmuir 27: 13159–13164. Available: http://dx.doi.org/10.1021/la202605z.
dc.identifier.issn0743-7463
dc.identifier.issn1520-5827
dc.identifier.pmid21928790
dc.identifier.doi10.1021/la202605z
dc.identifier.urihttp://hdl.handle.net/10754/597672
dc.description.abstractThe incorporation of silver nanoparticles (AgNPs) into polymeric nanofibers has attracted a great deal of attention due to the strong antimicrobial activity that the resulting fibers exhibit. However, bactericidal efficacy of AgNP-coated electrospun fibrous mats has not yet been demonstrated. In this study, polysulfone (PSf) fibers were electrospun and surface-modified using an oxygen plasma treatment, which allowed for facile irreversible deposition of cationically charged polyethyleneimine (PEI)-AgNPs via electrostatic interactions. The PSf-AgNP mats were characterized for relative silver concentration as a function of plasma treatment time using ICP-MS and changes in contact angle. Plasma treatment of 60 s was the shortest time required for maximum loss of bacteria (Escherichia coli) viability. Time-dependent bacterial cytotoxicity studies indicate that the optimized PSf-AgNP mats exhibit a high level of inactivation against both Gram negative bacteria, Escherichia coli, and Gram positive bacteria, Bacillus anthracis and Staphylococcus aureus. © 2011 American Chemical Society.
dc.description.sponsorshipThis publication was based on work supported by Award No. KUS-C1-018-02, made by King Abdullah University of Science and Technology (KAUST). We acknowledge use of facilities at the Cornell NanoScale Facility, a member of the National Nanotechnology Infrastructure Network, which is supported by the National Science Foundation (Grant ECS-0335765).
dc.publisherAmerican Chemical Society (ACS)
dc.titleBiocidal Activity of Plasma Modified Electrospun Polysulfone Mats Functionalized with Polyethyleneimine-Capped Silver Nanoparticles
dc.typeArticle
dc.identifier.journalLangmuir
dc.contributor.institutionYale University, New Haven, United States
dc.contributor.institutionCornell University, Ithaca, United States
dc.contributor.institutionUniversity of Massachusetts, Amherst MA, United States
kaust.grant.numberKUS-C1-018-02


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