An investigation of the influence of extracellular matrix anisotropy and cell–matrix interactions on tissue architecture
KAUST Grant NumberKUK-C1-013-04
Online Publication Date2015-09-02
Print Publication Date2016-06
Permanent link to this recordhttp://hdl.handle.net/10754/597538
MetadataShow full item record
Abstract© 2015 Springer-Verlag Berlin Heidelberg Mechanical interactions between cells and the fibrous extracellular matrix (ECM) in which they reside play a key role in tissue development. Mechanical cues from the environment (such as stress, strain and fibre orientation) regulate a range of cell behaviours, including proliferation, differentiation and motility. In turn, the ECM structure is affected by cells exerting forces on the matrix which result in deformation and fibre realignment. In this paper we develop a mathematical model to investigate this mechanical feedback between cells and the ECM. We consider a three-phase mixture of collagen, culture medium and cells, and formulate a system of partial differential equations which represents conservation of mass and momentum for each phase. This modelling framework takes into account the anisotropic mechanical properties of the collagen gel arising from its fibrous microstructure. We also propose a cell–collagen interaction force which depends upon fibre orientation and collagen density. We use a combination of numerical and analytical techniques to study the influence of cell–ECM interactions on pattern formation in tissues. Our results illustrate the wide range of structures which may be formed, and how those that emerge depend upon the importance of cell–ECM interactions.
CitationDyson RJ, Green JEF, Whiteley JP, Byrne HM (2015) An investigation of the influence of extracellular matrix anisotropy and cell–matrix interactions on tissue architecture. Journal of Mathematical Biology. Available: http://dx.doi.org/10.1007/s00285-015-0927-7.
SponsorsWe thank A.M. Soto and C. Sonnenschein (Tufts University) for the initial discussions which led to the development of the model, and D.J. Smith (University of Birmingham) for assistance with aspects of the numerics. RJD gratefully acknowledges the support of the University of Birmingham’s System Science for Health initiative and the hospitality of the School of Mathematical Sciences at the University of Adelaide. JEFG is supported by a Discovery Early Career Researcher Award (DE130100031) from the Australian Research Council. The work of HMB was supported in part by award KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).
JournalJournal of Mathematical Biology
CollectionsPublications Acknowledging KAUST Support
- Development of a three-dimensional unit cell to model the micromechanical response of a collagen-based extracellular matrix.
- Authors: Susilo ME, Roeder BA, Voytik-Harbin SL, Kokini K, Nauman EA
- Issue date: 2010 Apr
- Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes.
- Authors: Li Z, Tuffin J, Lei IM, Ruggeri FS, Lewis NS, Gill EL, Savin T, Huleihel L, Badylak SF, Knowles T, Satchell SC, Welsh GI, Saleem MA, Huang YYS
- Issue date: 2018 Sep 15
- Collagenous Extracellular Matrix Biomaterials for Tissue Engineering: Lessons from the Common Sea Urchin Tissue.
- Authors: Goh KL, Holmes DF
- Issue date: 2017 Apr 25
- Prediction of equibiaxial loading stress in collagen-based extracellular matrix using a three-dimensional unit cell model.
- Authors: Susilo ME, Bell BJ, Roeder BA, Voytik-Harbin SL, Kokini K, Nauman EA
- Issue date: 2013 Mar