Aldehyde-Selective Wacker-Type Oxidation of Unbiased Alkenes Enabled by a Nitrite Co-Catalyst
Type
ArticleDate
2013-09-13Online Publication Date
2013-09-13Print Publication Date
2013-10-18Permanent link to this record
http://hdl.handle.net/10754/597486
Metadata
Show full item recordAbstract
Breaking the rules: Reversal of the high Markovnikov selectivity of Wacker-type oxidations was accomplished using a nitrite co-catalyst. Unbiased aliphatic alkenes can be oxidized with high yield and aldehyde selectivity, and several functional groups are tolerated. 18O-labeling experiments indicate that the aldehydic O atom is derived from the nitrite salt.Citation
Wickens ZK, Morandi B, Grubbs RH (2013) Aldehyde-Selective Wacker-Type Oxidation of Unbiased Alkenes Enabled by a Nitrite Co-Catalyst. Angew Chem 125: 11467–11470. Available: http://dx.doi.org/10.1002/ange.201306756.Sponsors
We thank Scott Virgil for technical assistance. We acknowledge KAUST, KFUPM, and NSF for funding and the SNSF for a fellowship to B.M.Publisher
WileyJournal
Angewandte Chemieae974a485f413a2113503eed53cd6c53
10.1002/ange.201306756