A rapid and convergent synthesis of the integrastatin core
| dc.contributor.author | Tadross, Pamela M. | |
| dc.contributor.author | Bugga, Pradeep | |
| dc.contributor.author | Stoltz, Brian M. | |
| dc.date.accessioned | 2016-02-25T12:32:11Z | |
| dc.date.available | 2016-02-25T12:32:11Z | |
| dc.date.issued | 2011 | |
| dc.identifier.citation | Tadross PM, Bugga P, Stoltz BM (2011) A rapid and convergent synthesis of the integrastatin core. Org Biomol Chem 9: 5354. Available: http://dx.doi.org/10.1039/c1ob05725a. | |
| dc.identifier.issn | 1477-0520 | |
| dc.identifier.issn | 1477-0539 | |
| dc.identifier.pmid | 21681334 | |
| dc.identifier.doi | 10.1039/c1ob05725a | |
| dc.identifier.uri | http://hdl.handle.net/10754/597388 | |
| dc.description.abstract | The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(ii)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds. © 2011 The Royal Society of Chemistry. | |
| dc.description.sponsorship | This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Financial support from Caltech, the Rose Hills Foundation (undergraduate fellowship to P.B.), and the California HIV/AIDS Research Program (graduate fellowship to P.M.T.) is also gratefully acknowledged. | |
| dc.publisher | Royal Society of Chemistry (RSC) | |
| dc.title | A rapid and convergent synthesis of the integrastatin core | |
| dc.type | Article | |
| dc.identifier.journal | Organic & Biomolecular Chemistry | |
| dc.contributor.institution | California Institute of Technology, Pasadena, United States | |
| kaust.grant.number | KUS-11-006-02 |