A rapid and convergent synthesis of the integrastatin core

Type
Article

Authors
Tadross, Pamela M.
Bugga, Pradeep
Stoltz, Brian M.

KAUST Grant Number
KUS-11-006-02

Date
2011

Abstract
The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(ii)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds. © 2011 The Royal Society of Chemistry.

Citation
Tadross PM, Bugga P, Stoltz BM (2011) A rapid and convergent synthesis of the integrastatin core. Org Biomol Chem 9: 5354. Available: http://dx.doi.org/10.1039/c1ob05725a.

Acknowledgements
This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Financial support from Caltech, the Rose Hills Foundation (undergraduate fellowship to P.B.), and the California HIV/AIDS Research Program (graduate fellowship to P.M.T.) is also gratefully acknowledged.

Publisher
Royal Society of Chemistry (RSC)

Journal
Organic & Biomolecular Chemistry

DOI
10.1039/c1ob05725a

PubMed ID
21681334

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