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dc.contributor.authorGoldberg, Alexander F. G.
dc.contributor.authorStoltz, Brian M.
dc.date.accessioned2016-02-25T12:31:43Z
dc.date.available2016-02-25T12:31:43Z
dc.date.issued2011-08-19
dc.identifier.citationGoldberg AFG, Stoltz BM (2011) A Palladium-Catalyzed Vinylcyclopropane (3 + 2) Cycloaddition Approach to the Melodinus Alkaloids. Organic Letters 13: 4474–4476. Available: http://dx.doi.org/10.1021/ol2017615.
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.pmid21786746
dc.identifier.doi10.1021/ol2017615
dc.identifier.urihttp://hdl.handle.net/10754/597366
dc.description.abstractA palladium-catalyzed (3+2) cycloaddition of a vinylcyclopropane and a β-nitrostyrene is employed to rapidly assemble the cyclopentane core of the Melodinus alkaloids. The ABCD ring system of the natural product family is prepared in six steps from commercially available materials.
dc.description.sponsorshipThis publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). The authors wish to thank NTH-NIGMS (R01GM080269-01), Amgen, Abbott, Boehringer Ingelheim, and Caltech for financial support. A.G. gratefully acknowledges the Natural Sciences and Engineering Research Council (NSERC) of Canada for a PGS D scholarship. Christopher Henry, Hosea Nelson, Kristy Tran, Florian Vogt, and Scott Virgil (Caltech) are thanked for helpful guidance. Lawrence Henling and Dr. Michael Day (Caltech) are gratefully acknowledged for X-ray crystallographic structural determination. The Bruker KAPPA APEXII X-ray diffractometer was purchased via an NSF CRIF:MU award to the California Institute of Technology, CHE-0639094. The Varian 400 MHz NMR spectrometer was purchased via an NIH grant (RR027690).
dc.publisherAmerican Chemical Society (ACS)
dc.titleA Palladium-Catalyzed Vinylcyclopropane (3 + 2) Cycloaddition Approach to the Melodinus Alkaloids
dc.typeArticle
dc.identifier.journalOrganic Letters
dc.identifier.pmcidPMC3155617
dc.contributor.institutionThe Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 101-20, Pasadena, California 91125, USA.
kaust.grant.numberKUS-11-006-02


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