Show simple item record

dc.contributor.authorPerfahl, H.
dc.contributor.authorByrne, H. M.
dc.contributor.authorChen, T.
dc.contributor.authorEstrella, V.
dc.contributor.authorAlarcón, T.
dc.contributor.authorLapin, A.
dc.contributor.authorGatenby, R. A.
dc.contributor.authorGillies, R. J.
dc.contributor.authorLloyd, M. C.
dc.contributor.authorMaini, P. K.
dc.contributor.authorReuss, M.
dc.contributor.authorOwen, M. R.
dc.date.accessioned2016-02-25T12:28:07Z
dc.date.available2016-02-25T12:28:07Z
dc.date.issued2012-11-01
dc.identifier.citationPerfahl H, Byrne HM, Chen T, Estrella V, Alarcón T, et al. (2012) 3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth. Micro and Nano Flow Systems for Bioanalysis: 29–48. Available: http://dx.doi.org/10.1007/978-1-4614-4376-6_3.
dc.identifier.doi10.1007/978-1-4614-4376-6_3
dc.identifier.urihttp://hdl.handle.net/10754/597215
dc.description.abstractWe present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.
dc.description.sponsorshipHMB, MRO and HP acknowledge financial support by the Marie CurieNetwork MMBNOTT (Project No. MEST-CT-2005-020723). RAG and PKM acknowledge partialsupport from NIH/NCI grant U54CA143970. HP, AL and MR thank the BMBF—FundingInitiative FORSYS Partner: “Predictive Cancer Therapy”. In vivo window chamber work wasfunded in part by Moffitt Cancer Center PS-OC NIH/NCI U54CA143970. This publication wasbased on work supported in part by Award No. KUK-C1-1013-04, made by King AbdullahUniversity of Science and Technology (KAUST).
dc.publisherSpringer Science + Business Media
dc.title3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth
dc.typeBook Chapter
dc.identifier.journalMicro and Nano Flow Systems for Bioanalysis
dc.contributor.institutionCenter for Systems-Biology, University of Stuttgart, Stuttgart, Germany
dc.contributor.institutionOxford Centre for Collaborative Applied Mathematics, Department of Computer Science, University of Oxford, Oxford, UK
dc.contributor.institutionH. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA
dc.contributor.institutionCentre de Recerca Matemàtica, Campus de Bellaterra, Barcelona, Spain
dc.contributor.institutionCentre for Mathematical Biology, Mathematical Institute and Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, UK
dc.contributor.institutionCentre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, UK
kaust.grant.numberKUK-C1-1013-04


This item appears in the following Collection(s)

Show simple item record