3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth
Byrne, H. M.
Gatenby, R. A.
Gillies, R. J.
Lloyd, M. C.
Maini, P. K.
Owen, M. R.
KAUST Grant NumberKUK-C1-1013-04
Online Publication Date2012-11-01
Print Publication Date2013
Permanent link to this recordhttp://hdl.handle.net/10754/597215
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AbstractWe present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.
CitationPerfahl H, Byrne HM, Chen T, Estrella V, Alarcón T, et al. (2012) 3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth. Micro and Nano Flow Systems for Bioanalysis: 29–48. Available: http://dx.doi.org/10.1007/978-1-4614-4376-6_3.
SponsorsHMB, MRO and HP acknowledge financial support by the Marie CurieNetwork MMBNOTT (Project No. MEST-CT-2005-020723). RAG and PKM acknowledge partialsupport from NIH/NCI grant U54CA143970. HP, AL and MR thank the BMBF—FundingInitiative FORSYS Partner: “Predictive Cancer Therapy”. In vivo window chamber work wasfunded in part by Moffitt Cancer Center PS-OC NIH/NCI U54CA143970. This publication wasbased on work supported in part by Award No. KUK-C1-1013-04, made by King AbdullahUniversity of Science and Technology (KAUST).