Show simple item record

dc.contributor.authorLu, Liang
dc.contributor.authorWang, Jijie
dc.contributor.authorXu, Ying
dc.contributor.authorWang, Kailing
dc.contributor.authorHu, Yingwei
dc.contributor.authorTian, Renmao
dc.contributor.authorYang, Bo
dc.contributor.authorLai, Qiliang
dc.contributor.authorLi, Yongxin
dc.contributor.authorZhang, Weipeng
dc.contributor.authorShao, Zongze
dc.contributor.authorLam, Henry
dc.contributor.authorQian, Pei-Yuan
dc.date.accessioned2016-02-23T13:51:46Z
dc.date.available2016-02-23T13:51:46Z
dc.date.issued2014-10-09
dc.identifier.citationLu L, Wang J, Xu Y, Wang K, Hu Y, et al. (2014) A High-Resolution LC-MS-Based Secondary Metabolite Fingerprint Database of Marine Bacteria. Scientific Reports 4: 6537. Available: http://dx.doi.org/10.1038/srep06537.
dc.identifier.issn2045-2322
dc.identifier.pmid25298017
dc.identifier.doi10.1038/srep06537
dc.identifier.urihttp://hdl.handle.net/10754/596982
dc.description.abstract© 2014 Macmillan Publishers Limited. All rights reserved. Marine bacteria are the most widely distributed organisms in the ocean environment and produce a wide variety of secondary metabolites. However, traditional screening for bioactive natural compounds is greatly hindered by the lack of a systematic way of cataloguing the chemical profiles of bacterial strains found in nature. Here we present a chemical fingerprint database of marine bacteria based on their secondary metabolite profiles, acquired by high-resolution LC-MS. Till now, 1,430 bacterial strains spanning 168 known species collected from different marine environments were cultured and profiled. Using this database, we demonstrated that secondary metabolite profile similarity is approximately, but not always, correlated with taxonomical similarity. We also validated the ability of this database to find species-specific metabolites, as well as to discover known bioactive compounds from previously unknown sources. An online interface to this database, as well as the accompanying software, is provided freely for the community to use.
dc.description.sponsorshipThis study was supported by grants from the China Mineral Resources Research and
dc.publisherSpringer Nature
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleA High-Resolution LC-MS-Based Secondary Metabolite Fingerprint Database of Marine Bacteria
dc.typeArticle
dc.identifier.journalScientific Reports
dc.contributor.institutionHong Kong University of Science and Technology, Hong Kong, China
dc.contributor.institutionHong Kong University of Science and Technology, Hong Kong, China
dc.contributor.institutionHong Kong University of Science and Technology, Hong Kong, China
dc.contributor.institutionOcean University of China, Qingdao, China
dc.contributor.institutionHong Kong University of Science and Technology, Hong Kong, China
dc.contributor.institutionState Oceanic Administration China, Xiamen, China
kaust.grant.numberSA-C0040/UK-C0016
refterms.dateFOA2018-06-13T14:21:48Z


Files in this item

Thumbnail
Name:
srep06537.pdf
Size:
702.5Kb
Format:
PDF
Description:
Main article

This item appears in the following Collection(s)

Show simple item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/