Show simple item record

dc.contributor.authorD'Andrea, Daniel
dc.contributor.authorGrassi, Luigi
dc.contributor.authorMazzapioda, Mariagiovanna
dc.contributor.authorTramontano, Anna
dc.date.accessioned2016-02-21T08:50:38Z
dc.date.available2016-02-21T08:50:38Z
dc.date.issued2013-06-10
dc.identifier.citationD’Andrea D, Grassi L, Mazzapioda M, Tramontano A (2013) FIDEA: a server for the functional interpretation of differential expression analysis. Nucleic Acids Research 41: W84–W88. Available: http://dx.doi.org/10.1093/nar/gkt516.
dc.identifier.issn0305-1048
dc.identifier.issn1362-4962
dc.identifier.pmid23754850
dc.identifier.doi10.1093/nar/gkt516
dc.identifier.urihttp://hdl.handle.net/10754/596785
dc.description.abstractThe results of differential expression analyses provide scientists with hundreds to thousands of differentially expressed genes that need to be interpreted in light of the biology of the specific system under study. This requires mapping the genes to functional classifications that can be, for example, the KEGG pathways or InterPro families they belong to, their GO Molecular Function, Biological Process or Cellular Component. A statistically significant overrepresentation of one or more category terms in the set of differentially expressed genes is an essential step for the interpretation of the biological significance of the results. Ideally, the analysis should be performed by scientists who are well acquainted with the biological problem, as they have a wealth of knowledge about the system and can, more easily than a bioinformatician, discover less obvious and, therefore, more interesting relationships. To allow experimentalists to explore their data in an easy and at the same time exhaustive fashion within a single tool and to test their hypothesis quickly and effortlessly, we developed FIDEA. The FIDEA server is located at http://www.biocomputing.it/fidea; it is free and open to all users, and there is no login requirement.
dc.description.sponsorshipEpigenomics Flagship Project-EPIGEN; KAUST [KUK-I1-012-43]; PRIN Project [20108XYHJS]. Funding for open access charge: Epigenomics Flagship Project-EPIGEN.
dc.publisherOxford University Press (OUP)
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.subject.meshGene Expression Profiling
dc.subject.meshSoftware
dc.titleFIDEA: a server for the functional interpretation of differential expression analysis.
dc.typeArticle
dc.identifier.journalNucleic Acids Research
dc.identifier.pmcidPMC3692084
dc.contributor.institutionUniversita degli Studi di Roma La Sapienza, Rome, Italy
kaust.grant.numberKUK-I1-012-43
refterms.dateFOA2018-06-13T12:06:45Z


Files in this item

Thumbnail
Name:
PMC3692084.pdf
Size:
989.9Kb
Format:
PDF
Description:
Main article

This item appears in the following Collection(s)

Show simple item record

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com