KAUST Grant NumberKUK-C1-013-04
Online Publication Date2014-05-21
Print Publication Date2014-05-21
Permanent link to this recordhttp://hdl.handle.net/10754/596762
MetadataShow full item record
AbstractIn the human, placental structure is closely related to placental function and consequent pregnancy outcome. Studies have noted abnormal placental shape in small-for-gestational-age infants which extends to increased lifetime risk of cardiovascular disease. The origins and determinants of placental shape are incompletely understood and are difficult to study in vivo. In this paper, we model the early development of the human placenta, based on the hypothesis that this is driven by a chemoattractant effect emanating from proximal spiral arteries in the decidua. We derive and explore a two-dimensional stochastic model, and investigate the effects of loss of spiral arteries in regions near to the cord insertion on the shape of the placenta. This model demonstrates that disruption of spiral arteries can exert profound effects on placental shape, particularly if this is close to the cord insertion. Thus, placental shape reflects the underlying maternal vascular bed. Abnormal placental shape may reflect an abnormal uterine environment, predisposing to pregnancy complications. Through statistical analysis of model placentas, we are able to characterize the probability that a given placenta grew in a disrupted environment, and even able to distinguish between different disruptions.
CitationCotter SL, Klika V, Kimpton L, Collins S, Heazell AEP (2014) A stochastic model for early placental development. Journal of The Royal Society Interface 11: 20140149–20140149. Available: http://dx.doi.org/10.1098/rsif.2014.0149.
SponsorsThe Study Group and a subsequent follow-up meeting were supported by the Engineering and Physical Sciences Research Council (EP/H00162X/1), and hosted by OCCAM, Mathematical Institute, University of Oxford, UK, with institutional support RVO:68407700 for V. K. This publication is based on work supported in part by award no. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).
PublisherThe Royal Society
PubMed Central IDPMC4208356
CollectionsPublications Acknowledging KAUST Support
Except where otherwise noted, this item's license is described as © 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License , which permits unrestricted use, provided the original author and source are credited.
- Placental bed research: II. Functional and immunological investigations of the placental bed.
- Authors: Harris LK, Benagiano M, D'Elios MM, Brosens I, Benagiano G
- Issue date: 2019 Nov
- Placental bed research: I. The placental bed: from spiral arteries remodeling to the great obstetrical syndromes.
- Authors: Brosens I, Puttemans P, Benagiano G
- Issue date: 2019 Nov
- Centrality of the umbilical cord insertion in a human placenta influences the placental efficiency.
- Authors: Yampolsky M, Salafia CM, Shlakhter O, Haas D, Eucker B, Thorp J
- Issue date: 2009 Dec
- Pathophysiology of placental-derived fetal growth restriction.
- Authors: Burton GJ, Jauniaux E
- Issue date: 2018 Feb
- Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies.
- Authors: Kala S, Dunk C, Acosta S, Serghides L
- Issue date: 2020 Aug 1