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    Anti-cancer Lead Molecule

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    Name:
    20140107196.pdf
    Size:
    3.186Mb
    Format:
    PDF
    Description:
    Patent
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    Type
    Patent
    Patent Status
    Granted Patent
    Authors
    Sagar, Sunil
    Kaur, Mandeep
    Esau, Luke E.
    Assignee
    King Abdullah University of Science and Technology
    KAUST Department
    Computational Bioscience Research Center (CBRC)
    Technology Transfer
    Date
    2014-04-17
    Submitted Date
    2013-03-13
    Permanent link to this record
    http://hdl.handle.net/10754/594844
    
    Metadata
    Show full item record
    Abstract
    Derivatives of plumbagin can be selectively cytotoxic to breast cancer cells. Derivative `A` (Acetyl Plumbagin) has emerged as a lead molecule for testing against estrogen positive breast cancer and has shown low hepatotoxicity as well as overall lower toxicity in nude mice model. The toxicity of derivative `A` was determined to be even lower than vehicle control (ALT and AST markers). The possible mechanism of action identified based on the microarray experiments and pathway mapping shows that derivative `A` could be acting by altering the cholesterol-related mechanisms. The low toxicity profile of derivative `A` highlights its possible role as future anti-cancer drug and/or as an adjuvant drug to reduce the toxicity of highly toxic chemotherapeutic drugs
    Patent Number
    US9890106B2
    Application Number
    US 20140107196 A1
    Additional Links
    http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220140107196%22.PGNR.&OS=DN/20140107196&RS=DN/20140107196
    http://assignment.uspto.gov/#/search?adv=publNum:20140107196
    http://www.google.com/patents/US20140107196
    http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=2014107196A1&KC=A1&FT=D
    Collections
    Patents; Computational Bioscience Research Center (CBRC)

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