In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

Ashraf, Ayesha; Sharif, Rehana; Ahmad, Munir; Masood, Misbah; Shahid, Abubakar; Anjum, Dalaver H.; Rafique, Muhammad Shahid; Ghani, Sheeba

Type

Article

Authors

Ashraf, Ayesha
Sharif, Rehana
Ahmad, Munir
Masood, Misbah
Shahid, Abubakar
Anjum, Dalaver H.

Rafique, Muhammad Shahid
Ghani, Sheeba

KAUST Department

Electron Microscopy
Imaging and Characterization Core Lab
Nanofabrication Core Lab

Date

2015-12-01

Permanent link to this record

http://hdl.handle.net/10754/594278

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Abstract

Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment. © 2015 The Institution of Engineering and Technology.

Citation

OCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"><html> <head> <title>Current Links for doi: 10.1049/iet-nbt.2014.0075</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><link rel="stylesheet" rev="stylesheet" type="text/css" href="/docs/iPage/css/iet_body.css"> </head> <body bgcolor="#FFFFFF"> <table width="57%"> <tr> <td><a href="http://www.theiet.org"><img src="/docs/iPage/images/iet.gif" alt="Institution of Engineering and Technology" border="0" align="left"></a></td></tr> <tr> <td><br/></td> </tr> <tr> <td>The IET is a world leading professional organisation sharing and advancing knowledge to promote science, engineering and technology across the world. <br> <hr> </td> </tr> </table> <table width="57%"> <tr> <td><tr><td><b>In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit</b></td></tr><tr><td>Ashraf,Ayesha et al.</td></tr><tr><td><i>IET Nanobiotechnology</i>(2015),9(6):368</td></tr><tr><td><a href='http://dx.doi.org/10.1049/iet-nbt.2014.0075'>http://dx.doi.org/10.1049/iet-nbt.2014.0075</td></tr></td> <tr> <tr><td><hr></td></tr> </table> <table width="57%"> <tr> <td colspan="2"> This article is available from multiple sources. <b>Please click on the logo</b> of the service to which you have a subscription, or click any logo to obtain pay-per-view access.<br><br></td> </tr> <tr> <td width="35%"><a href="http://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2014.0075"><img src="/docs/iPage/images/idl.gif" border="0" alt="IET Digital Library on Scitation"></a></td> <td width="65%"><br>  Access the IET Digital Library<br><br></td> </tr> <tr> <td><br/><br/></td> </tr> <tr> <td><a href="http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=7350376"><img src="/docs/iPage/images/iel.gif" border="0" alt="IEL on IEEE Xplore"></a></td> <td><br>  Access the IEL (IEEE/IET Electronic Library) on IEEE Xplore®</a><br><br></td></td> </tr> </table> </body></html>