KAUST DepartmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Permanent link to this recordhttp://hdl.handle.net/10754/594268
MetadataShow full item record
AbstractThis work, focusing on an implantable drug delivery system, presents the first prototype electrolytic pump that combines a catalytic reformer and a cyclically actuated mode. These features improve the release performance and extend the lifetime of the device. Using our platinum (Pt)-coated carbon fiber mesh that acts as a catalytic reforming element, the cyclical mode is improved because the faster recombination rate allows for a shorter cycling time for drug delivery. Another feature of our device is that it uses a solid-drug-in-reservoir (SDR) approach, which allows small amounts of a solid drug to be dissolved in human fluid, forming a reproducible drug solution for long-term therapies. We have conducted proof-of-principle drug delivery studies using such an electrolytic pump and solvent blue 38 as the drug substitute. These tests demonstrate power-controlled and pulsatile release profiles of the chemical substance, as well as the feasibility of this device. A drug delivery rate of 11.44 ± 0.56 μg min-1 was achieved by using an input power of 4 mW for multiple pulses, which indicates the stability of our system. © The Royal Society of Chemistry 2015.
CitationYi Y, Buttner U, Foulds IG (2015) A cyclically actuated electrolytic drug delivery device. Lab Chip 15: 3540–3548. Available: http://dx.doi.org/10.1039/c5lc00703h.
PublisherRoyal Society of Chemistry (RSC)
- A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve.
- Authors: Yi Y, Zaher A, Yassine O, Kosel J, Foulds IG
- Issue date: 2015 Sep
- Low-power microfluidic electro-hydraulic pump (EHP).
- Authors: Lui C, Stelick S, Cady N, Batt C
- Issue date: 2010 Jan 7
- Concept for a gas-cell-driven drug delivery system for therapeutic applications.
- Authors: Becker S, Xu T, Ilchmann F, Eisler J, Wolf B
- Issue date: 2011 Dec
- An implantable MEMS drug delivery device for rapid delivery in ambulatory emergency care.
- Authors: Elman NM, Ho Duc HL, Cima MJ
- Issue date: 2009 Jun
- An implantable thermoresponsive drug delivery system based on Peltier device.
- Authors: Yang R, Gorelov AV, Aldabbagh F, Carroll WM, Rochev Y
- Issue date: 2013 Apr 15