TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
Di Domizio, Jeremy
Voo, Kui S
Friedrich, Heike C
Le Roy, Didier
Ladbury, John E
Modlin, Robert L
Kontoyiannis, Dimitrios P
Arold, Stefan T.
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AbstractInterleukin 17-producing helper T cells (TH 17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. © 2015 Nature America, Inc.
CitationMeller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, et al. (2015) TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol 16: 970–979. Available: http://dx.doi.org/10.1038/ni.3211.
PublisherNature Publishing Group
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