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    TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

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    T17 cell promote.pdf
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    Description:
    Accepted manuscript
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    Type
    Article
    Authors
    Meller, Stephan
    Di Domizio, Jeremy
    Voo, Kui S
    Friedrich, Heike C
    Chamilos, Georgios
    Ganguly, Dipyaman
    Conrad, Curdin
    Gregorio, Josh
    Le Roy, Didier
    Roger, Thierry cc
    Ladbury, John E
    Homey, Bernhard
    Watowich, Stanley
    Modlin, Robert L
    Kontoyiannis, Dimitrios P
    Liu, Yong-Jun
    Arold, Stefan T. cc
    Gilliet, Michel
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Date
    2015-07-13
    Online Publication Date
    2015-07-13
    Print Publication Date
    2015-09
    Permanent link to this record
    http://hdl.handle.net/10754/594165
    
    Metadata
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    Abstract
    Interleukin 17-producing helper T cells (TH 17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. © 2015 Nature America, Inc.
    Citation
    Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, et al. (2015) TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol 16: 970–979. Available: http://dx.doi.org/10.1038/ni.3211.
    Publisher
    Springer Nature
    Journal
    Nature Immunology
    DOI
    10.1038/ni.3211
    PubMed ID
    26168081
    ae974a485f413a2113503eed53cd6c53
    10.1038/ni.3211
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Computational Bioscience Research Center (CBRC)

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