TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
Type
ArticleAuthors
Meller, StephanDi Domizio, Jeremy
Voo, Kui S
Friedrich, Heike C
Chamilos, Georgios
Ganguly, Dipyaman
Conrad, Curdin
Gregorio, Josh
Le Roy, Didier
Roger, Thierry

Ladbury, John E
Homey, Bernhard
Watowich, Stanley
Modlin, Robert L
Kontoyiannis, Dimitrios P
Liu, Yong-Jun
Arold, Stefan T.

Gilliet, Michel
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Computational Bioscience Research Center (CBRC)
Date
2015-07-13Online Publication Date
2015-07-13Print Publication Date
2015-09Permanent link to this record
http://hdl.handle.net/10754/594165
Metadata
Show full item recordAbstract
Interleukin 17-producing helper T cells (TH 17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. © 2015 Nature America, Inc.Citation
Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, et al. (2015) TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol 16: 970–979. Available: http://dx.doi.org/10.1038/ni.3211.Publisher
Springer NatureJournal
Nature ImmunologyDOI
10.1038/ni.3211PubMed ID
26168081ae974a485f413a2113503eed53cd6c53
10.1038/ni.3211
Scopus Count
Related articles
- IL-26 AMPs up the T(H)17 arsenal.
- Authors: Lee JS, Cua DJ
- Issue date: 2015 Sep
- T cells: A killer cytokine.
- Authors: Bird L
- Issue date: 2015 Aug
- Psoriasis and other Th17-mediated skin diseases.
- Authors: Tokura Y, Mori T, Hino R
- Issue date: 2010 Dec 1
- Antimicrobial peptides and self-DNA in autoimmune skin inflammation.
- Authors: Gilliet M, Lande R
- Issue date: 2008 Aug
- Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
- Authors: Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Schröder JM, Liu YJ, Gilliet M
- Issue date: 2007 Oct 4