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dc.contributor.authorZhao, Wei
dc.contributor.authorGnanou, Yves
dc.contributor.authorHadjichristidis, Nikos
dc.date.accessioned2016-01-19T13:20:57Z
dc.date.available2016-01-19T13:20:57Z
dc.date.issued2015
dc.identifier.citationZhao W, Gnanou Y, Hadjichristidis N (2015) Organocatalysis by hydrogen-bonding: a new approach to controlled/living polymerization of α-amino acid N-carboxyanhydrides. Polym Chem 6: 6193–6201. Available: http://dx.doi.org/10.1039/c5py00874c.
dc.identifier.issn1759-9954
dc.identifier.issn1759-9962
dc.identifier.doi10.1039/c5py00874c
dc.identifier.urihttp://hdl.handle.net/10754/594074
dc.description.abstractA new method, based on hydrogen-bonding organocatalysis, was developed to achieve living ring-opening polymerization of N-carboxyanhydride of α-amino acids using aminoalcohols as initiators in the presence of N,N′-bis[3,5-bis(trifluoromethyl)phenyl]thiourea (TU-S). The thiourea provides, through hydrogen bonding, simultaneous activation of NCA monomers/reversible deactivation of polymer chain-ends/silencing of the tertiary amine and thus allows the polymerization to proceed in a highly controllable mode. For example, by using N,N-dimethyl ethanolamine (DMEA), as an initiator in the presence of TU-S, a series of well-defined linear polypeptides with differently designed Mns (3.01 × 104-18.10 × 104) and low PDI values (1.02-1.05) were successfully synthesized. This general strategy was also extended to the synthesis of well-defined di- and multi-armed polypeptides by using di-, tri-, or tetra-aminoalcohol initiators (methyldiethanolamine (MDEA), triethanolamine (TEA) or N,N,N′,N′-tetrakis(2-hydroxyethyl)ethylenediamine (THEED)) in the presence of TU-S. © The Royal Society of Chemistry 2015.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleOrganocatalysis by hydrogen-bonding: a new approach to controlled/living polymerization of α-amino acid N-carboxyanhydrides
dc.typeArticle
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentPolymer Synthesis Laboratory
dc.identifier.journalPolymer Chemistry
kaust.personZhao, Wei
kaust.personGnanou, Yves
kaust.personHadjichristidis, Nikos


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