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dc.contributor.authorPerez, Jose E.
dc.contributor.authorContreras, Maria F.
dc.contributor.authorVidal, Enrique Vilanova
dc.contributor.authorFelix Servin, Laura P.
dc.contributor.authorMargineanu, Michael B.
dc.contributor.authorLuongo, Giovanni
dc.contributor.authorPorter, Alexandra E.
dc.contributor.authorDunlop, Iain E.
dc.contributor.authorRavasi, Timothy
dc.contributor.authorKosel, Jürgen
dc.date.accessioned2016-01-05T06:09:01Z
dc.date.available2016-01-05T06:09:01Z
dc.date.issued2016-02-05
dc.identifier.citationCytotoxicity and intracellular dissolution of nickel nanowires 2015:1 Nanotoxicology
dc.identifier.issn1743-5390
dc.identifier.issn1743-5404
dc.identifier.pmid26692167
dc.identifier.doi10.3109/17435390.2015.1132343
dc.identifier.urihttp://hdl.handle.net/10754/592811
dc.description.abstractThe assessment of cytotoxicity of nanostructures is a fundamental step for their development as biomedical tools. As widely used nanostructures, nickel nanowires (Ni NWs) seem promising candidates for such applications. In this work, Ni NWs were synthesized and then characterized using vibrating sample magnetometry, energy dispersive X-Ray analysis and electron microscopy. After exposure to the NWs, cytotoxicity was evaluated in terms of cell viability, cell membrane damage and induced apoptosis/necrosis on the model human cell line HCT 116. The influence of NW to cell ratio (10:1 to 1000:1) and exposure times up to 72 hours was analyzed for Ni NWs of 5.4 µm in length, as well as for Ni ions. The results show that cytotoxicity markedly increases past 24 hours of incubation. Cellular uptake of NWs takes place through the phagocytosis pathway, with a fraction of the dose of NWs dissolved inside the cells. Cell death results from a combination of apoptosis and necrosis, where the latter is the outcome of the secondary necrosis pathway. The cytotoxicity of Ni ions and Ni NWs dissolution studies suggest a synergistic toxicity between NW aspect ratio and dissolved Ni, with the cytotoxic effects markedly increasing after 24 hours of incubation.
dc.language.isoen
dc.publisherInforma UK Limited
dc.relation.urlhttp://www.tandfonline.com/doi/full/10.3109/17435390.2015.1132343
dc.rightsThis is an Accepted Manuscript of an article published by Taylor & Francis in Nanotoxicology on 22 Dec 2015, available online: http://wwww.tandfonline.com/10.3109/17435390.2015.1132343.
dc.subjectnanotoxicology
dc.subjectparticle charactarization
dc.subjectnanomedicine
dc.subjectmagnetic nanowires
dc.subjectnanoparticles
dc.titleCytotoxicity and intracellular dissolution of nickel nanowires
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentChemical and Biological Engineering Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentEntrepreneurship Center
dc.identifier.journalNanotoxicology
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Materials, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personPerez, Jose E.
kaust.personContreras, Maria F.
kaust.personVidal, Enrique Vilanova
kaust.personFelix Servin, Laura P.
kaust.personMargineanu, Michael B.
kaust.personRavasi, Timothy
kaust.personKosel, Jürgen
dc.relation.issupplementedbyDOI:10.6084/M9.FIGSHARE.C.2169857
refterms.dateFOA2016-12-22T00:00:00Z
display.relations<b> Is Supplemented By:</b> <br/> <ul><li><i>[Dataset]</i> <br/> Perez, J. E., Contreras, M. F., Vilanova, E., Felix, L. P., Margineanu, M. B., Luongo, G., … Kosel, J. (2016). Cytotoxicity and intracellular dissolution of nickel nanowires. Figshare. https://doi.org/10.6084/m9.figshare.c.2169857. DOI: <a href="https://doi.org/10.6084/M9.FIGSHARE.C.2169857">10.6084/M9.FIGSHARE.C.2169857</a> HANDLE: <a href="http://hdl.handle.net/10754/624123">10754/624123</a></li></ul>
display.relations<b> Is Supplemented By:</b> <br/> <ul> <li><i>[Dataset]</i> <br/> . DOI: <a href="https://doi.org/10.6084/m9.figshare.1626721">10.6084/m9.figshare.1626721</a> HANDLE: <a href="http://hdl.handle.net/10754/663599">10754/663599</a></li></ul>
dc.date.published-online2016-02-05
dc.date.published-print2016-08-08


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