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    Cytotoxicity and intracellular dissolution of nickel nanowires

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    Type
    Article
    Authors
    Perez, Jose E. cc
    Contreras, Maria F. cc
    Vidal, Enrique Vilanova
    Felix Servin, Laura P.
    Margineanu, Michael B. cc
    Luongo, Giovanni
    Porter, Alexandra E.
    Dunlop, Iain E.
    Ravasi, Timothy cc
    Kosel, Jürgen cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Chemical and Biological Engineering Program
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Entrepreneurship Center
    Date
    2016-02-05
    Online Publication Date
    2016-02-05
    Print Publication Date
    2016-08-08
    Permanent link to this record
    http://hdl.handle.net/10754/592811
    
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    Abstract
    The assessment of cytotoxicity of nanostructures is a fundamental step for their development as biomedical tools. As widely used nanostructures, nickel nanowires (Ni NWs) seem promising candidates for such applications. In this work, Ni NWs were synthesized and then characterized using vibrating sample magnetometry, energy dispersive X-Ray analysis and electron microscopy. After exposure to the NWs, cytotoxicity was evaluated in terms of cell viability, cell membrane damage and induced apoptosis/necrosis on the model human cell line HCT 116. The influence of NW to cell ratio (10:1 to 1000:1) and exposure times up to 72 hours was analyzed for Ni NWs of 5.4 µm in length, as well as for Ni ions. The results show that cytotoxicity markedly increases past 24 hours of incubation. Cellular uptake of NWs takes place through the phagocytosis pathway, with a fraction of the dose of NWs dissolved inside the cells. Cell death results from a combination of apoptosis and necrosis, where the latter is the outcome of the secondary necrosis pathway. The cytotoxicity of Ni ions and Ni NWs dissolution studies suggest a synergistic toxicity between NW aspect ratio and dissolved Ni, with the cytotoxic effects markedly increasing after 24 hours of incubation.
    Citation
    Cytotoxicity and intracellular dissolution of nickel nanowires 2015:1 Nanotoxicology
    Publisher
    Informa UK Limited
    Journal
    Nanotoxicology
    DOI
    10.3109/17435390.2015.1132343
    PubMed ID
    26692167
    Additional Links
    http://www.tandfonline.com/doi/full/10.3109/17435390.2015.1132343
    Relations
    Is Supplemented By:
    • [Dataset]
      Perez, J. E., Contreras, M. F., Vilanova, E., Felix, L. P., Margineanu, M. B., Luongo, G., … Kosel, J. (2016). Cytotoxicity and intracellular dissolution of nickel nanowires. Figshare. https://doi.org/10.6084/m9.figshare.c.2169857. DOI: 10.6084/M9.FIGSHARE.C.2169857 HANDLE: 10754/624123

    Is Supplemented By:
    • [Dataset]
      . DOI: 10.6084/m9.figshare.1626721 HANDLE: 10754/663599
    ae974a485f413a2113503eed53cd6c53
    10.3109/17435390.2015.1132343
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Electrical Engineering Program; Chemical Engineering Program; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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