Disrupting astrocyte–neuron lactate transfer persistently reduces conditioned responses to cocaine
dc.contributor.author | Boury-Jamot, B | |
dc.contributor.author | Carrard, A | |
dc.contributor.author | Martin, J L | |
dc.contributor.author | Halfon, O | |
dc.contributor.author | Magistretti, Pierre J. | |
dc.contributor.author | Boutrel, B | |
dc.date.accessioned | 2015-12-27T13:25:10Z | |
dc.date.available | 2015-12-27T13:25:10Z | |
dc.date.issued | 2015-10-27 | |
dc.identifier.citation | Disrupting astrocyte–neuron lactate transfer persistently reduces conditioned responses to cocaine 2015 Molecular Psychiatry | |
dc.identifier.issn | 1359-4184 | |
dc.identifier.issn | 1476-5578 | |
dc.identifier.doi | 10.1038/mp.2015.157 | |
dc.identifier.uri | http://hdl.handle.net/10754/592604 | |
dc.description.abstract | A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memory reconsolidation represents a potential therapeutic strategy, the role of astrocyte–neuron lactate transport in long-term conditioning has received little attention. By infusing an inhibitor of glycogen phosphorylase into the basolateral amygdala of rats, we report that disruption of astrocyte-derived lactate not only transiently impaired the acquisition of a cocaine-induced conditioned place preference but also persistently disrupted an established conditioning. The drug memory was rescued by L-Lactate co-administration through a mechanism requiring the synaptic plasticity-related transcription factor Zif268 and extracellular signal-regulated kinase (ERK) signalling pathway but not the brain-derived neurotrophic factor (Bdnf). The long-term amnesia induced by glycogenolysis inhibition and the concomitant decreased expression of phospho-ERK were both restored with L-Lactate co-administration. These findings reveal a critical role for astrocyte-derived lactate in positive memory formation and highlight a novel amygdala-dependent reconsolidation process, whose disruption may offer a novel therapeutic target to reduce the long-lasting conditioned responses to cocaine. | |
dc.language.iso | en | |
dc.publisher | Springer Nature | |
dc.relation.url | http://www.nature.com/doifinder/10.1038/mp.2015.157 | |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. | |
dc.title | Disrupting astrocyte–neuron lactate transfer persistently reduces conditioned responses to cocaine | |
dc.type | Article | |
dc.contributor.department | Biological and Environmental Sciences and Engineering (BESE) Division | |
dc.contributor.department | Bioscience Program | |
dc.identifier.journal | Molecular Psychiatry | |
dc.eprint.version | Publisher's Version/PDF | |
dc.contributor.institution | Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland | |
dc.contributor.institution | Division of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland | |
dc.contributor.institution | Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland | |
dc.contributor.affiliation | King Abdullah University of Science and Technology (KAUST) | |
kaust.person | Magistretti, Pierre J. | |
refterms.dateFOA | 2018-06-13T12:39:00Z | |
dc.date.published-online | 2015-10-27 | |
dc.date.published-print | 2016-08 |
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