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dc.contributor.authorPetit, Jean-Marie
dc.contributor.authorMagistretti, Pierre J.
dc.date.accessioned2015-12-21T06:20:47Z
dc.date.available2015-12-21T06:20:47Z
dc.date.issued2015-12-18
dc.identifier.citationRegulation of Neuron-Astrocyte Metabolic Coupling across the Sleep-Wake Cycle 2015 Neuroscience
dc.identifier.issn03064522
dc.identifier.pmid26704637
dc.identifier.doi10.1016/j.neuroscience.2015.12.007
dc.identifier.urihttp://hdl.handle.net/10754/584242
dc.description.abstractOver the last thirty years, a growing number of studies showed that astrocytes play a pivotal role in the energy support to synapses. More precisely, astrocytes adjust the energy production to the neuronal energy needs through different mechanisms grouped under the term “neurometabolic coupling” (NMC). In this review we describe these mechanisms of coupling and how they involve astrocytes. From a physiological point of view, these mechanisms of coupling are particularly important to ensure normal synaptic functioning when neurons undergo rapid and repetitive changes in firing rate such as during the sleep/wake transitions. Investigations on brain energy metabolism during the sleep/wake cycle have been mainly focused on glucose consumption and on glycogen metabolism. However, the recent development of substrate-specific biosensors allowed measurements of the variation in extracellular levels of glutamate, glucose and lactate with a time resolution compatible with sleep stage duration. Together with gene expression data these experiments allowed to better define the variations of energy metabolites regulation across the sleep/wake cycle. The aim of this review is to bring into perspective the role of astrocytes and neurometabolic coupling in the regulation of the sleep/wake cycle. The data reviewed also suggest an important role of the astrocytic network. In addition, the role of astrocytes in NMC mechanisms is consistent with the “local and use dependent” sleep hypothesis.
dc.language.isoen
dc.publisherElsevier BV
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0306452215010908
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Neuroscience. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuroscience, 17 December 2015. DOI: 10.1016/j.neuroscience.2015.12.007
dc.subjectLactate
dc.subjectGlucose
dc.subjectGlutamate
dc.subjectAdenosine
dc.subjectLocus coeruleus
dc.subjectGap-junctions
dc.titleRegulation of Neuron-Astrocyte Metabolic Coupling across the Sleep-Wake Cycle
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalNeuroscience
dc.eprint.versionPost-print
dc.contributor.institutionCentre de Neurosciences Psychiatriques, Centre Hospitalier Universitaire Vaudois, Hôpital de Cery, Prilly, Switzerland
dc.contributor.institutionLaboratoire de Neuroénergétique et Dynamique Cellulaire, Brain Mind Institute, Faculté des Sciences de la Vie, EPFL, Lausanne, Switzerland
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personMagistretti, Pierre J.
refterms.dateFOA2016-12-17T00:00:00Z
dc.date.published-online2015-12-18
dc.date.published-print2016-05


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