One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere
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Xinbo Wang-org letts-2015.pdf
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ArticleKAUST Department
Advanced Membranes and Porous Materials Research CenterChemical Engineering Program
Chemical Science Program
Homogeneous Catalysis Laboratory (HCL)
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2015-11-06Online Publication Date
2015-11-06Print Publication Date
2015-11-20Permanent link to this record
http://hdl.handle.net/10754/583936
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A facile one-pot synthesis of N-(α-peroxy)indole and N-(α-peroxy)carbazole has been developed using metal-free, organo-acid-catalyzed three-component condensation reactions of indole/carbazole, aldehyde, and peroxide. Based on the reaction discovered, a new synthetic proposal for Fumitremorgin A and Verruculogen is introduced. Such a protocol could be easily handled and scaled up in an open atmosphere with a wide substrate scope, enabling the construction of a new molecule library.Citation
One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere 2015, 17 (22):5630 Organic LettersPublisher
American Chemical Society (ACS)Journal
Organic LettersPubMed ID
26541059Additional Links
http://pubs.acs.org/doi/10.1021/acs.orglett.5b02881Relations
Is Supplemented By:- [Dataset]
Wang, X., Pan, Y., Huang, K.-W., & Lai, Z. (2015). CCDC 1438644: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc1k90wr. DOI: 10.5517/cc1k90wr HANDLE: 10754/624487
ae974a485f413a2113503eed53cd6c53
10.1021/acs.orglett.5b02881
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