One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere
Name:
Xinbo Wang-org letts-2015.pdf
Size:
943.2Kb
Format:
PDF
Description:
Accepted Manuscript
Type
Article
KAUST Department
Advanced Membranes and Porous Materials Research CenterChemical Engineering Program
Chemical Science Program
Homogeneous Catalysis Laboratory (HCL)
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2015-11-06Online Publication Date
2015-11-06Print Publication Date
2015-11-20Permanent link to this record
http://hdl.handle.net/10754/583936Metadata
Show full item recordAbstract
A facile one-pot synthesis of N-(α-peroxy)indole and N-(α-peroxy)carbazole has been developed using metal-free, organo-acid-catalyzed three-component condensation reactions of indole/carbazole, aldehyde, and peroxide. Based on the reaction discovered, a new synthetic proposal for Fumitremorgin A and Verruculogen is introduced. Such a protocol could be easily handled and scaled up in an open atmosphere with a wide substrate scope, enabling the construction of a new molecule library.Citation
One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere 2015, 17 (22):5630 Organic LettersPublisher
American Chemical Society (ACS)Journal
Organic LettersPubMed ID
26541059Additional Links
http://pubs.acs.org/doi/10.1021/acs.orglett.5b02881Relations
Is Supplemented By:- [Dataset]
Wang, X., Pan, Y., Huang, K.-W., & Lai, Z. (2015). CCDC 1438644: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc1k90wr. DOI: 10.5517/cc1k90wr HANDLE: 10754/624487