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    One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere

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    Name:
    Xinbo Wang-org letts-2015.pdf
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    943.2Kb
    Format:
    PDF
    Description:
    Accepted Manuscript
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    Type
    Article
    Authors
    Wang, Xinbo
    Pan, Yupeng
    Huang, Kuo-Wei cc
    Lai, Zhiping cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Chemical Engineering Program
    Chemical Science Program
    Homogeneous Catalysis Laboratory (HCL)
    KAUST Catalysis Center (KCC)
    Physical Science and Engineering (PSE) Division
    Date
    2015-11-06
    Online Publication Date
    2015-11-06
    Print Publication Date
    2015-11-20
    Permanent link to this record
    http://hdl.handle.net/10754/583936
    
    Metadata
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    Abstract
    A facile one-pot synthesis of N-(α-peroxy)indole and N-(α-peroxy)carbazole has been developed using metal-free, organo-acid-catalyzed three-component condensation reactions of indole/carbazole, aldehyde, and peroxide. Based on the reaction discovered, a new synthetic proposal for Fumitremorgin A and Verruculogen is introduced. Such a protocol could be easily handled and scaled up in an open atmosphere with a wide substrate scope, enabling the construction of a new molecule library.
    Citation
    One-Pot Synthesis of N-(α-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere 2015, 17 (22):5630 Organic Letters
    Publisher
    American Chemical Society (ACS)
    Journal
    Organic Letters
    DOI
    10.1021/acs.orglett.5b02881
    PubMed ID
    26541059
    Additional Links
    http://pubs.acs.org/doi/10.1021/acs.orglett.5b02881
    Relations
    Is Supplemented By:
    • [Dataset]
      Wang, X., Pan, Y., Huang, K.-W., & Lai, Z. (2015). CCDC 1438644: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc1k90wr. DOI: 10.5517/cc1k90wr HANDLE: 10754/624487
    ae974a485f413a2113503eed53cd6c53
    10.1021/acs.orglett.5b02881
    Scopus Count
    Collections
    Articles; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Chemical Science Program; Chemical Engineering Program; KAUST Catalysis Center (KCC)

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