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    The Arabidopsis gene DIG6 encodes a large 60S subunit nuclear export GTPase 1 that is involved in ribosome biogenesis and affects multiple auxin-regulated development processes

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    J. Exp. Bot.-2015-Zhao-6863-75.pdf
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    Type
    Article
    Authors
    Zhao, Huayan
    Lü, Shiyou
    Li, Ruixi
    Chen, Tao
    Zhang, Huoming cc
    Cui, Peng cc
    Ding, Feng cc
    Liu, Pei-Nian cc
    Wang, Guangchao
    Xia, Yiji
    Running, Mark P.
    Xiong, Liming cc
    KAUST Department
    Analytical Chemistry Core Lab
    Analytical Core Lab
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Core Lab
    Desert Agriculture Initiative
    Imaging and Characterization Core Lab
    Plant Science
    Date
    2015-08-13
    Online Publication Date
    2015-08-13
    Print Publication Date
    2015-11
    Permanent link to this record
    http://hdl.handle.net/10754/583295
    
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    Abstract
    The circularly permuted GTPase large subunit GTPase 1 (LSG1) is involved in the maturation step of the 60S ribosome and is essential for cell viability in yeast. Here, an Arabidopsis mutant dig6 (drought inhibited growth of lateral roots) was isolated. The mutant exhibited multiple auxin-related phenotypes, which included reduced lateral root number, altered leaf veins, and shorter roots. Genetic mapping combined with next-generation DNA sequencing identified that the mutation occurred in AtLSG1-2. This gene was highly expressed in regions of auxin accumulation. Ribosome profiling revealed that a loss of function of AtLSG1-2 led to decreased levels of monosomes, further demonstrating its role in ribosome biogenesis. Quantitative proteomics showed that the expression of certain proteins involved in ribosome biogenesis was differentially regulated, indicating that ribosome biogenesis processes were impaired in the mutant. Further investigations showed that an AtLSG1-2 deficiency caused the alteration of auxin distribution, response, and transport in plants. It is concluded that AtLSG1-2 is integral to ribosome biogenesis, consequently affecting auxin homeostasis and plant development.
    Citation
    The Arabidopsis gene DIG6 encodes a large 60S subunit nuclear export GTPase 1 that is involved in ribosome biogenesis and affects multiple auxin-regulated development processes 2015, 66 (21):6863 Journal of Experimental Botany
    Publisher
    Oxford University Press (OUP)
    Journal
    Journal of Experimental Botany
    DOI
    10.1093/jxb/erv391
    PubMed ID
    26272902
    Additional Links
    http://jxb.oxfordjournals.org/lookup/doi/10.1093/jxb/erv391
    ae974a485f413a2113503eed53cd6c53
    10.1093/jxb/erv391
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Analytical Chemistry Core Lab; Imaging and Characterization Core Lab; Bioscience Core Lab; Desert Agriculture Initiative

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