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dc.contributor.authorTempleton, Thomas J.
dc.contributor.authorPain, Arnab
dc.date.accessioned2015-12-01T13:42:27Z
dc.date.available2015-12-01T13:42:27Z
dc.date.issued2015-11-20
dc.identifier.citationDiversity of extracellular proteins during the transition from the ‘proto-apicomplexan’ alveolates to the apicomplexan obligate parasites 2015:1 Parasitology
dc.identifier.issn0031-1820
dc.identifier.issn1469-8161
dc.identifier.pmid26585326
dc.identifier.doi10.1017/S0031182015001213
dc.identifier.urihttp://hdl.handle.net/10754/583074
dc.description.abstractThe recent completion of high-coverage draft genome sequences for several alveolate protozoans – namely, the chromerids, Chromera velia and Vitrella brassicaformis ; the perkinsid Perkinsus marinus ; the apicomplexan, Gregarina niphandrodes , as well as high coverage transcriptome sequence information for several colpodellids, allows for new genome-scale comparisons across a rich landscape of apicomplexans and other alveolates. Genome annotations can now be used to help interpret fine ultrastructure and cell biology, and guide new studies to describe a variety of alveolate life strategies, such as symbiosis or free living, predation, and obligate intracellular parasitism, as well to provide foundations to dissect the evolutionary transitions between these niches. This review focuses on the attempt to identify extracellular proteins which might mediate the physical interface of cell–cell interactions within the above life strategies, aided by annotation of the repertoires of predicted surface and secreted proteins encoded within alveolate genomes. In particular, we discuss what descriptions of the predicted extracellular proteomes reveal regarding a hypothetical last common ancestor of a pre-apicomplexan alveolate – guided by ultrastructure, life strategies and phylogenetic relationships – in an attempt to understand the evolution of obligate parasitism in apicomplexans.
dc.language.isoen
dc.publisherCambridge University Press (CUP)
dc.relation.urlhttp://www.journals.cambridge.org/abstract_S0031182015001213
dc.rightsArchived with thanks to Parasitology. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.subjectApicomplexa
dc.subjectChromera
dc.subjectPlasmodium
dc.subjectColpodella
dc.subjectVitrella
dc.subjectAlveolata
dc.subjectToxoplasma
dc.subjectPerkinsus
dc.subjectCryptosporidium
dc.subjectGregarina
dc.titleDiversity of extracellular proteins during the transition from the ‘proto-apicomplexan’ alveolates to the apicomplexan obligate parasites
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentPathogen Genomics Laboratory
dc.identifier.journalParasitology
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
dc.contributor.institutionDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York 10021, USA
dc.contributor.institutionGlobal Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, N20 W10 Kita-ku, Sapporo 001-0020, Japan
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personPain, Arnab
refterms.dateFOA2018-06-13T13:37:05Z
dc.date.published-online2015-11-20
dc.date.published-print2016-01


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