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    A System-Wide Approach to Identify the Mechanisms of Barnacle Attachment: Toward the Discovery of New Antifouling Compounds

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    Name:
    SarahAl-AqeelDissertation.pdf
    Size:
    3.886Mb
    Format:
    PDF
    Description:
    Final Dissertation
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    Type
    Dissertation
    Authors
    Al-Aqeel, Sarah cc
    Advisors
    Ravasi, Timothy cc
    Committee members
    Qian, Pei-Yuan cc
    Pinnau, Ingo cc
    Voolstra, Christian R. cc
    Program
    Chemical and Biological Engineering
    KAUST Department
    Physical Science and Engineering (PSE) Division
    Date
    2015-11
    Embargo End Date
    2016-07-01
    Permanent link to this record
    http://hdl.handle.net/10754/582250
    
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    Show full item record
    Access Restrictions
    At the time of archiving, the student author of this dissertation opted to temporarily restrict access to it. The full text of this dissertation became available to the public after the expiration of the embargo on 2016-07-01.
    Abstract
    Biofouling is a significant economic problem, particularly for marine and offshore oil industries. The acorn barnacle (Amphibalanus (Balanus) amphitrite) is the main biofouling organism in marine environments. Environmental conditions, the physiology of the biofouling organism, the surrounding microbial community, and the properties of the substratum can all influence the attachment of biofouling organisms to substrates. My dissertation investigated the biological processes involved in B. amphitrite development and attachment in the unique environment of the Red Sea, where the average water surface temperature is 34°C and the salinity reaches 41‰. I profiled the transcriptome and proteome of B. amphitrite at different life stages (nauplius II, nauplius VI, and cyprid) and identified 65,784 expressed contigs and 1387 expressed proteins by quantitative proteomics. During the planktonic stage, genes related to osmotic stress, salt stress, the hyperosmotic response, and the Wnt signaling pathway were strongly up-regulated, hereas genes related to the MAPK pathway, lipid metabolism, and cuticle development were down-regulated. In the transition from the nauplius VI to cyprid stages, there was up-regulation of genes involved in blood coagulation, cuticle development, and eggshell formation, and down-regulation of genes in the nitric oxide pathway, which stimulates the swimming and feeding responses of marine invertebrates. This system-wide integrated approach elucidated the development and attachment pathways important in B. amphitrite. Enzymes and metabolites in these pathways are potential molecular targets for the development of new antifouling compounds.
    Citation
    Al-Aqeel, S. (2015). A System-Wide Approach to Identify the Mechanisms of Barnacle Attachment: Toward the Discovery of New Antifouling Compounds. KAUST Research Repository. https://doi.org/10.25781/KAUST-4Q83V
    DOI
    10.25781/KAUST-4Q83V
    ae974a485f413a2113503eed53cd6c53
    10.25781/KAUST-4Q83V
    Scopus Count
    Collections
    Dissertations; Physical Science and Engineering (PSE) Division; Chemical Engineering Program

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