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    Hollow ZIF-8 Nanoworms from Block Copolymer Templates

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    srep15275.pdf
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    Type
    Article
    Authors
    Yu, Haizhou
    Qiu, Xiaoyan
    Neelakanda, Pradeep
    Deng, Lin cc
    Khashab, Niveen M. cc
    Nunes, Suzana Pereira cc
    Peinemann, Klaus-Viktor cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Biological and Environmental Sciences and Engineering (BESE) Division
    Chemical Engineering Program
    Chemical Science Program
    Environmental Science and Engineering Program
    Nanostructured Polymeric Membrane Lab
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    Date
    2015-10-16
    Online Publication Date
    2015-10-16
    Print Publication Date
    2015-12
    Permanent link to this record
    http://hdl.handle.net/10754/581362
    
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    Abstract
    Recently two quite different types of “nano-containers” have been recognized as attractive potential drug carriers; these are wormlike filamenteous micelles (“filomicelles”) on the one hand and metal organic frameworks on the other hand. In this work we combine these two concepts. We report for the first time the manufacturing of metal organic framework nanotubes with a hollow core. These worm-like tubes are about 200 nm thick and several μm long. The preparation is simple: we first produce long and flexible filament-shaped micelles by block copolymer self-assembly. These filomicelles serve as templates to grow a very thin layer of interconnected ZIF-8 crystals on their surface. Finally the block copolymer is removed by solvent extraction and the hollow ZIF-8 nanotubes remain. These ZIF-NTs are surprisingly stable and withstand purification by centrifugation. The synthesis method is straightforward and can easily be applied for other metal organic framework materials. The ZIF-8 NTs exhibit high loading capacity for the model anti cancer drug doxorubicin (DOX) with a pH-triggered release. Hence, a prolonged circulation in the blood stream and a targeted drug release behavior can be expected.
    Citation
    Hollow ZIF-8 Nanoworms from Block Copolymer Templates 2015, 5:15275 Scientific Reports
    Publisher
    Springer Nature
    Journal
    Scientific Reports
    DOI
    10.1038/srep15275
    PubMed ID
    26471862
    Additional Links
    http://www.nature.com/articles/srep15275
    ae974a485f413a2113503eed53cd6c53
    10.1038/srep15275
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Advanced Membranes and Porous Materials Research Center; Environmental Science and Engineering Program; Physical Science and Engineering (PSE) Division; Chemical Science Program; Chemical Engineering Program

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