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dc.contributor.authorWang, Jianli
dc.contributor.authorLee, Alison P
dc.contributor.authorKodzius, Rimantas
dc.contributor.authorBrenner, Sydney
dc.contributor.authorVenkatesh, Byrappa
dc.date.accessioned2015-10-26T13:28:10Z
dc.date.available2015-10-26T13:28:10Z
dc.date.issued2009-03
dc.identifier.citationLarge number of ultraconserved elements were already present in the jawed vertebrate ancestor. 2009, 26 (3):487-90 Mol. Biol. Evol.
dc.identifier.issn1537-1719
dc.identifier.issn0737-4038
dc.identifier.pmid19052148
dc.identifier.doi10.1093/molbev/msn278
dc.identifier.urihttp://hdl.handle.net/10754/581116
dc.description.abstractStephen (2008) identified 13,736 ultraconserved elements (UCEs) in placental mammals and investigated their evolution in opossum, chicken, frog, and fugu. They found that there was a massive expansion of UCEs during tetrapod evolution and the substitution rate in UCEs showed a significant decline in tetrapods compared with fugu, suggesting they were exapted in tetrapods. They considered it unlikely that these elements are ancient but evolved at a higher rate in teleost fishes. In this study, we investigated the evolution of UCEs in a cartilaginous fish, the elephant shark and show that nearly half the UCEs were present in the jawed vertebrate ancestor. The substitution rate in UCEs is higher in fugu than in elephant shark, and approximately one-third of ancient UCEs have diverged beyond recognition in teleost fishes. These data indicate that UCEs have evolved at a higher rate in teleost fishes, which may have implications for their vast diversity and evolutionary success.
dc.language.isoen
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.relation.urlhttp://mbe.oxfordjournals.org/content/26/3/487.long
dc.rightsArchived with thanks to Molecular biology and evolution
dc.subjectUltraconserved elements
dc.subjectelephant shark
dc.subjectTeleost fish
dc.subject.meshAnimals
dc.subject.meshBiological Evolution
dc.subject.meshChickens
dc.subject.meshConserved Sequence
dc.subject.meshFishes
dc.subject.meshGenome
dc.subject.meshHumans
dc.subject.meshOpossums
dc.subject.meshPhylogeny
dc.subject.meshRanidae
dc.subject.meshVertebrates
dc.titleLarge number of ultraconserved elements were already present in the jawed vertebrate ancestor.
dc.typeArticle
dc.identifier.eissn1537-1719
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.identifier.journalMolecular Biology and Evolution
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionInstitute of Molecular and Cell Biology (IMCB)
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personKodzius, Rimantas
refterms.dateFOA2018-06-13T13:36:14Z


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