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dc.contributor.authorWang, Jianli*
dc.contributor.authorLee, Alison P*
dc.contributor.authorKodzius, Rimantas*
dc.contributor.authorBrenner, Sydney*
dc.contributor.authorVenkatesh, Byrappa*
dc.date.accessioned2015-10-26T13:28:10Zen
dc.date.available2015-10-26T13:28:10Zen
dc.date.issued2009-03en
dc.identifier.citationLarge number of ultraconserved elements were already present in the jawed vertebrate ancestor. 2009, 26 (3):487-90 Mol. Biol. Evol.en
dc.identifier.issn1537-1719en
dc.identifier.issn0737-4038en
dc.identifier.pmid19052148en
dc.identifier.doi10.1093/molbev/msn278en
dc.identifier.urihttp://hdl.handle.net/10754/581116en
dc.description.abstractStephen (2008) identified 13,736 ultraconserved elements (UCEs) in placental mammals and investigated their evolution in opossum, chicken, frog, and fugu. They found that there was a massive expansion of UCEs during tetrapod evolution and the substitution rate in UCEs showed a significant decline in tetrapods compared with fugu, suggesting they were exapted in tetrapods. They considered it unlikely that these elements are ancient but evolved at a higher rate in teleost fishes. In this study, we investigated the evolution of UCEs in a cartilaginous fish, the elephant shark and show that nearly half the UCEs were present in the jawed vertebrate ancestor. The substitution rate in UCEs is higher in fugu than in elephant shark, and approximately one-third of ancient UCEs have diverged beyond recognition in teleost fishes. These data indicate that UCEs have evolved at a higher rate in teleost fishes, which may have implications for their vast diversity and evolutionary success.en
dc.language.isoenen
dc.language.isoenen
dc.publisherOxford University Press (OUP)en
dc.relation.urlhttp://mbe.oxfordjournals.org/content/26/3/487.longen
dc.rightsArchived with thanks to Molecular biology and evolutionen
dc.subjectUltraconserved elementsen
dc.subjectelephant sharken
dc.subjectTeleost fishen
dc.subject.meshAnimalsen
dc.subject.meshBiological Evolutionen
dc.subject.meshChickensen
dc.subject.meshConserved Sequenceen
dc.subject.meshFishesen
dc.subject.meshGenomeen
dc.subject.meshHumansen
dc.subject.meshOpossumsen
dc.subject.meshPhylogenyen
dc.subject.meshRanidaeen
dc.subject.meshVertebratesen
dc.titleLarge number of ultraconserved elements were already present in the jawed vertebrate ancestor.en
dc.typeArticleen
dc.identifier.eissn1537-1719en
dc.contributor.departmentComputational Bioscience Research Center (CBRC)*
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division*
dc.identifier.journalMolecular Biology and Evolutionen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionInstitute of Molecular and Cell Biology (IMCB)*
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)*
kaust.authorKodzius, Rimantas*
refterms.dateFOA2018-06-13T13:36:14Z


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