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    Large number of ultraconserved elements were already present in the jawed vertebrate ancestor.

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    Large Number of Ultraconserved Elements Were Already Present in the Jawed Vertebrate Ancestor.pdf
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    Large Number of Ultraconserved Elements Were Already Present in the Jawed Vertebrate Ancestor
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    Type
    Article
    Authors
    Wang, Jianli
    Lee, Alison P
    Kodzius, Rimantas cc
    Brenner, Sydney
    Venkatesh, Byrappa
    KAUST Department
    Competitive Research Funds
    Computational Bioscience Research Center (CBRC)
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    OCRF- Special Academic Partnership
    Physical Science and Engineering (PSE) Division
    Date
    2008-12-23
    Permanent link to this record
    http://hdl.handle.net/10754/581116
    
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    Abstract
    Stephen (2008) identified 13,736 ultraconserved elements (UCEs) in placental mammals and investigated their evolution in opossum, chicken, frog, and fugu. They found that there was a massive expansion of UCEs during tetrapod evolution and the substitution rate in UCEs showed a significant decline in tetrapods compared with fugu, suggesting they were exapted in tetrapods. They considered it unlikely that these elements are ancient but evolved at a higher rate in teleost fishes. In this study, we investigated the evolution of UCEs in a cartilaginous fish, the elephant shark and show that nearly half the UCEs were present in the jawed vertebrate ancestor. The substitution rate in UCEs is higher in fugu than in elephant shark, and approximately one-third of ancient UCEs have diverged beyond recognition in teleost fishes. These data indicate that UCEs have evolved at a higher rate in teleost fishes, which may have implications for their vast diversity and evolutionary success.
    Citation
    Large number of ultraconserved elements were already present in the jawed vertebrate ancestor. 2009, 26 (3):487-90 Mol. Biol. Evol.
    Publisher
    Oxford University Press (OUP)
    Journal
    Molecular Biology and Evolution
    DOI
    10.1093/molbev/msn278
    PubMed ID
    19052148
    Additional Links
    http://mbe.oxfordjournals.org/content/26/3/487.long
    ae974a485f413a2113503eed53cd6c53
    10.1093/molbev/msn278
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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