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    Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels

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    Type
    Article
    Authors
    Shi, Junfeng
    Yuan, Dan
    Haburcak, Richard
    Zhang, Qiang cc
    Zhao, Chao cc
    Zhang, Xixiang cc
    Xu, Bing
    KAUST Department
    Imaging and Characterization Core Lab
    Material Science and Engineering Program
    Nanofabrication Core Lab
    Physical Characterization
    Physical Science and Engineering (PSE) Division
    Thin Films & Characterization
    Date
    2015-10-29
    Online Publication Date
    2015-10-29
    Print Publication Date
    2015-12-07
    Permanent link to this record
    http://hdl.handle.net/10754/579911
    
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    Abstract
    Enzyme-catalyzed dephosphorylation is essential for biomineralization and bone metabolism. Here we report the exploration of using enzymatic reaction to transform biocomposites of phosphopeptides and calcium (or strontium) ions to supramolecular hydrogels as a mimic of enzymatic dissolution of biominerals. 31P NMR shows that strong affinity between the phosphopeptides and alkaline metal ions (e.g., Ca2+ or Sr2+) induces the formation of biocomposites as precipitates. Electron microscopy reveals that the enzymatic reaction regulates the morphological transition from particles to nanofibers. Rheology confirms the formation of a rigid hydrogel. As the first example of enzyme-instructed dissolution of a solid to form supramolecular nanofibers/hydrogels, this work provides an approach to generate soft materials with desired properties, expands the application of supramolecular hydrogelators, and offers insights to control the demineralization of calcified soft tissues.
    Citation
    Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels 2015:n/a Chemistry - A European Journal
    Publisher
    Wiley
    Journal
    Chemistry - A European Journal
    DOI
    10.1002/chem.201504087
    PubMed ID
    26462722
    Additional Links
    http://doi.wiley.com/10.1002/chem.201504087
    ae974a485f413a2113503eed53cd6c53
    10.1002/chem.201504087
    Scopus Count
    Collections
    Nanofabrication Core Lab; Articles; Imaging and Characterization Core Lab; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program

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