Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels
Type
ArticleKAUST Department
Imaging and Characterization Core LabMaterial Science and Engineering Program
Nanofabrication Core Lab
Physical Characterization
Physical Science and Engineering (PSE) Division
Thin Films & Characterization
Date
2015-10-29Online Publication Date
2015-10-29Print Publication Date
2015-12-07Permanent link to this record
http://hdl.handle.net/10754/579911
Metadata
Show full item recordAbstract
Enzyme-catalyzed dephosphorylation is essential for biomineralization and bone metabolism. Here we report the exploration of using enzymatic reaction to transform biocomposites of phosphopeptides and calcium (or strontium) ions to supramolecular hydrogels as a mimic of enzymatic dissolution of biominerals. 31P NMR shows that strong affinity between the phosphopeptides and alkaline metal ions (e.g., Ca2+ or Sr2+) induces the formation of biocomposites as precipitates. Electron microscopy reveals that the enzymatic reaction regulates the morphological transition from particles to nanofibers. Rheology confirms the formation of a rigid hydrogel. As the first example of enzyme-instructed dissolution of a solid to form supramolecular nanofibers/hydrogels, this work provides an approach to generate soft materials with desired properties, expands the application of supramolecular hydrogelators, and offers insights to control the demineralization of calcified soft tissues.Citation
Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels 2015:n/a Chemistry - A European JournalPublisher
WileyJournal
Chemistry - A European JournalPubMed ID
26462722Additional Links
http://doi.wiley.com/10.1002/chem.201504087ae974a485f413a2113503eed53cd6c53
10.1002/chem.201504087
Scopus Count
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