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dc.contributor.authorJégu, Teddy
dc.contributor.authorDomenichini, Séverine
dc.contributor.authorBlein, Thomas
dc.contributor.authorAriel, Federico
dc.contributor.authorChrist, Aurélie
dc.contributor.authorKim, SoonKap
dc.contributor.authorCrespi, Martin
dc.contributor.authorBoutet-Mercey, Stéphanie
dc.contributor.authorMouille, Grégory
dc.contributor.authorBourge, Mickaël
dc.contributor.authorHirt, Heribert
dc.contributor.authorBergounioux, Catherine
dc.contributor.authorRaynaud, Cécile
dc.contributor.authorBenhamed, Moussa
dc.date.accessioned2015-10-18T14:48:16Z
dc.date.available2015-10-18T14:48:16Z
dc.date.issued2015-10-12
dc.identifier.citationA SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture 2015, 10 (10):e0138276 PLOS ONE
dc.identifier.issn1932-6203
dc.identifier.pmid26457678
dc.identifier.doi10.1371/journal.pone.0138276
dc.identifier.urihttp://hdl.handle.net/10754/579847
dc.description.abstractChromatin architecture determines transcriptional accessibility to DNA and consequently gene expression levels in response to developmental and environmental stimuli. Recently, chromatin remodelers such as SWI/SNF complexes have been recognized as key regulators of chromatin architecture. To gain insight into the function of these complexes during root development, we have analyzed Arabidopsis knock-down lines for one sub-unit of SWI/SNF complexes: BAF60. Here, we show that BAF60 is a positive regulator of root development and cell cycle progression in the root meristem via its ability to down-regulate cytokinin production. By opposing both the deposition of active histone marks and the formation of a chromatin regulatory loop, BAF60 negatively regulates two crucial target genes for cytokinin biosynthesis (IPT3 and IPT7) and one cell cycle inhibitor (KRP7). Our results demonstrate that SWI/SNF complexes containing BAF60 are key factors governing the equilibrium between formation and dissociation of a chromatin loop controlling phytohormone production and cell cycle progression.
dc.language.isoen
dc.publisherPublic Library of Science (PLoS)
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0138276
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://creativecommons.org/licenses/by/4.0/
dc.titleA SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentPlant Science
dc.identifier.journalPLoS ONE
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionInstitut de Biologie des Plantes, UMR8618 CNRS-Université Paris-Sud XI, Saclay Plant Sciences, Orsay, France
dc.contributor.institutionInstitut des Sciences du Végétal, UPR2355 CNRS, Saclay Plant Sciences, Gif-sur-Yvette, France
dc.contributor.institutionInstitut Jean-Pierre Bourgin, UMR1318 INRA/AgroParisTech, Versailles, France
dc.contributor.institutionPôle de Biologie Cellulaire, Imagif, Centre de Recherche de Gif, CNRS, IFR87, Gif-sur-Yvette, France
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personKim, SoonKap
kaust.personHirt, Heribert
kaust.personBenhamed, Moussa
refterms.dateFOA2018-06-13T10:20:33Z


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