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    Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes

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    Type
    Article
    Authors
    Zaher, Amir cc
    Li, S.
    Wolf, K. T.
    Pirmoradi, F. N.
    Yassine, Omar cc
    Lin, L.
    Khashab, Niveen M. cc
    Kosel, Jürgen cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Chemical Science Program
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Physical Science and Engineering (PSE) Division
    Sensing, Magnetism and Microsystems Lab
    Smart Hybrid Materials (SHMs) lab
    Date
    2015-09-29
    Online Publication Date
    2015-09-29
    Print Publication Date
    2015-09
    Permanent link to this record
    http://hdl.handle.net/10754/579156
    
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    Abstract
    Implantable drug delivery systems can provide long-term reliability, controllability, and biocompatibility, and have been used in many applications, including cancer pain and non-malignant pain treatment. However, many of the available systems are limited to zero-order, inconsistent, or single burst event drug release. To address these limitations, we demonstrate prototypes of a remotely operated drug delivery device that offers controllability of drug release profiles, using osmotic pumping as a pressure source and magnetically triggered membranes as switchable on-demand valves. The membranes are made of either ethyl cellulose, or the proposed stronger cellulose acetate polymer, mixed with thermosensitive poly(N-isopropylacrylamide) hydrogel and superparamagnetic iron oxide particles. The prototype devices' drug diffusion rates are on the order of 0.5–2 μg/h for higher release rate designs, and 12–40 ng/h for lower release rates, with maximum release ratios of 4.2 and 3.2, respectively. The devices exhibit increased drug delivery rates with higher osmotic pumping rates or with magnetically increased membrane porosity. Furthermore, by vapor deposition of a cyanoacrylate layer, a drastic reduction of the drug delivery rate from micrograms down to tens of nanograms per hour is achieved. By utilizing magnetic membranes as the valve-control mechanism, triggered remotely by means of induction heating, the demonstrated drug delivery devices benefit from having the power source external to the system, eliminating the need for a battery. These designs multiply the potential approaches towards increasing the on-demand controllability and customizability of drug delivery profiles in the expanding field of implantable drug delivery systems, with the future possibility of remotely controlling the pressure source.
    Citation
    Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes 2015, 9 (5):054113 Biomicrofluidics
    Publisher
    AIP Publishing
    Journal
    Biomicrofluidics
    DOI
    10.1063/1.4931954
    PubMed ID
    26487899
    Additional Links
    http://scitation.aip.org/content/aip/journal/bmf/9/5/10.1063/1.4931954
    ae974a485f413a2113503eed53cd6c53
    10.1063/1.4931954
    Scopus Count
    Collections
    Articles; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Electrical Engineering Program; Chemical Science Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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