Osmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes
Wolf, K. T.
Pirmoradi, F. N.
Khashab, Niveen M.
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Chemical Science Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Physical Science and Engineering (PSE) Division
Sensing, Magnetism and Microsystems Lab
Smart Hybrid Materials (SHMs) lab
Online Publication Date2015-09-29
Print Publication Date2015-09
Permanent link to this recordhttp://hdl.handle.net/10754/579156
MetadataShow full item record
AbstractImplantable drug delivery systems can provide long-term reliability, controllability, and biocompatibility, and have been used in many applications, including cancer pain and non-malignant pain treatment. However, many of the available systems are limited to zero-order, inconsistent, or single burst event drug release. To address these limitations, we demonstrate prototypes of a remotely operated drug delivery device that offers controllability of drug release profiles, using osmotic pumping as a pressure source and magnetically triggered membranes as switchable on-demand valves. The membranes are made of either ethyl cellulose, or the proposed stronger cellulose acetate polymer, mixed with thermosensitive poly(N-isopropylacrylamide) hydrogel and superparamagnetic iron oxide particles. The prototype devices' drug diffusion rates are on the order of 0.5–2 μg/h for higher release rate designs, and 12–40 ng/h for lower release rates, with maximum release ratios of 4.2 and 3.2, respectively. The devices exhibit increased drug delivery rates with higher osmotic pumping rates or with magnetically increased membrane porosity. Furthermore, by vapor deposition of a cyanoacrylate layer, a drastic reduction of the drug delivery rate from micrograms down to tens of nanograms per hour is achieved. By utilizing magnetic membranes as the valve-control mechanism, triggered remotely by means of induction heating, the demonstrated drug delivery devices benefit from having the power source external to the system, eliminating the need for a battery. These designs multiply the potential approaches towards increasing the on-demand controllability and customizability of drug delivery profiles in the expanding field of implantable drug delivery systems, with the future possibility of remotely controlling the pressure source.
CitationOsmotically driven drug delivery through remote-controlled magnetic nanocomposite membranes 2015, 9 (5):054113 Biomicrofluidics
CollectionsArticles; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Electrical and Computer Engineering Program; Chemical Science Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division
- A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve.
- Authors: Yi Y, Zaher A, Yassine O, Kosel J, Foulds IG
- Issue date: 2015 Sep
- Materials to clinical devices: technologies for remotely triggered drug delivery.
- Authors: Timko BP, Kohane DS
- Issue date: 2012 Nov
- Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release.
- Authors: Hoare T, Timko BP, Santamaria J, Goya GF, Irusta S, Lau S, Stefanescu CF, Lin D, Langer R, Kohane DS
- Issue date: 2011 Mar 9
- Light-switchable systems for remotely controlled drug delivery.
- Authors: Shim G, Ko S, Kim D, Le QV, Park GT, Lee J, Kwon T, Choi HG, Kim YB, Oh YK
- Issue date: 2017 Dec 10
- In vitro and in vivo studies of subcutaneous hydromorphone implants designed for the treatment of cancer pain.
- Authors: Lesser GJ, Grossman SA, Leong KW, Lo H, Eller S
- Issue date: 1996 May-Jun