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dc.contributor.authorWong, Aloysius Tze
dc.contributor.authorNgu, Davey Yueh Saint
dc.contributor.authorDan, Lydia Annabel
dc.contributor.authorOoi, Amanda Siok Lee
dc.contributor.authorLim, Renee Lay Hong
dc.date.accessioned2015-09-29T05:29:24Z
dc.date.available2015-09-29T05:29:24Z
dc.date.issued2015-09-14
dc.identifier.citationDetection of antibiotic resistance in probiotics of dietary supplements 2015, 14 (1) Nutrition Journal
dc.identifier.issn1475-2891
dc.identifier.pmid26370532
dc.identifier.doi10.1186/s12937-015-0084-2
dc.identifier.urihttp://hdl.handle.net/10754/578844
dc.description.abstractBackground Probiotics are live microorganisms that confer nutrition- and health-promoting benefits if consumed in adequate amounts. Concomitant with the demand for natural approaches to maintaining health is an increase in inclusion of probiotics in food and health products. Since probiotic bacteria act as reservoir for antibiotic resistant determinants, the transfer of these genes to pathogens sharing the same intestinal habitat is thus conceivable considering the fact that dietary supplements contain high amounts of often heterogeneous populations of probiotics. Such events can confer pathogens protection against commonly-used drugs. Despite numerous reports of antibiotic resistant probiotics in food and biological sources, the antibiogram of probiotics from dietary supplements remained elusive. Findings Here, we screened five commercially available dietary supplements for resistance towards antibiotics of different classes. Probiotics of all batches of products were resistant towards vancomycin while batch-dependent resistance towards streptomycin, aztreonam, gentamycin and/or ciprofloxacin antibiotics was detected for probiotics of brands Bi and Bn, Bg, and L. Isolates of brand Cn was also resistant towards gentamycin, streptomycin and ciprofloxacin antibiotics. Additionally, we also report a discrepancy between the enumerated viable bacteria amounts and the claims of the manufacturers. Conclusions This short report has highlighted the present of antibiotic resistance in probiotic bacteria from dietary supplements and therefore serves as a platform for further screenings and for in-depth characterization of the resistant determinants and the molecular machinery that confers the resistance.
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.urlhttp://www.nutritionj.com/content/14/1/95
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.titleDetection of antibiotic resistance in probiotics of dietary supplements
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalNutrition Journal
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionUCSI University, No. 1, Jalan Menara Gading, UCSI Heights, Cheras, Kuala Lumpur, 56000, Malaysia
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personWong, Aloysius Tze
kaust.personOoi, Amanda Siok Lee
dc.relation.isSupplementedByWong, A., Ngu, D., Dan, L., Ooi, A., & Lim, R. (2015). Detection of antibiotic resistance in probiotics of dietary supplements. Figshare. https://doi.org/10.6084/m9.figshare.c.3697372
dc.relation.isSupplementedByDOI:10.6084/m9.figshare.c.3697372
dc.relation.isSupplementedByHANDLE:http://hdl.handle.net/10754/624145
refterms.dateFOA2018-06-13T13:05:51Z


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