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dc.contributor.authorFatieiev, Yevhen
dc.contributor.authorCroissant, Jonas G.
dc.contributor.authorAlsaiari, Shahad K.
dc.contributor.authorMoosa, Basem
dc.contributor.authorAnjum, Dalaver H.
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2015-09-29T05:16:10Z
dc.date.available2015-09-29T05:16:10Z
dc.date.issued2015-09-25
dc.identifier.citationPhotoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery 2015:150925103151004 ACS Applied Materials & Interfaces
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.pmid26406224
dc.identifier.doi10.1021/acsami.5b07365
dc.identifier.urihttp://hdl.handle.net/10754/578841
dc.description.abstractBridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale –unlike most reported bridged silsesquioxane materials– with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.
dc.language.isoen
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttp://pubs.acs.org/doi/10.1021/acsami.5b07365
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/10.1021/acsami.5b07365.
dc.titlePhotoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery
dc.typeArticle
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.contributor.departmentImaging and Characterization Core Lab
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.identifier.journalACS Applied Materials & Interfaces
dc.eprint.versionPost-print
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personKhashab, Niveen M.
kaust.personFatieiev, Yevhen
kaust.personCroissant, Jonas G.
kaust.personAlsaiari, Shahad K.
kaust.personMoosa, Basem
kaust.personAnjum, Dalaver H.
refterms.dateFOA2016-09-25T00:00:00Z


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