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    Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

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    acsami2E5b07365.pdf
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    Description:
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    Type
    Article
    Authors
    Fatieiev, Yevhen cc
    Croissant, Jonas G.
    Alsaiari, Shahad K. cc
    Moosa, Basem cc
    Anjum, Dalaver H. cc
    Khashab, Niveen M. cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Bioscience Program
    Chemical Science Program
    Electron Microscopy
    Imaging and Characterization Core Lab
    Investment Fund
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    Date
    2015-09-29
    Online Publication Date
    2015-09-29
    Print Publication Date
    2015-11-18
    Permanent link to this record
    http://hdl.handle.net/10754/578841
    
    Metadata
    Show full item record
    Abstract
    Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale –unlike most reported bridged silsesquioxane materials– with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.
    Citation
    Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery 2015:150925103151004 ACS Applied Materials & Interfaces
    Publisher
    American Chemical Society (ACS)
    Journal
    ACS Applied Materials & Interfaces
    DOI
    10.1021/acsami.5b07365
    PubMed ID
    26406224
    Additional Links
    http://pubs.acs.org/doi/10.1021/acsami.5b07365
    ae974a485f413a2113503eed53cd6c53
    10.1021/acsami.5b07365
    Scopus Count
    Collections
    Articles; Bioscience Program; Advanced Membranes and Porous Materials Research Center; Imaging and Characterization Core Lab; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

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