Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery
Type
ArticleAuthors
Fatieiev, Yevhen
Croissant, Jonas G.
Alsaiari, Shahad K.

Moosa, Basem

Anjum, Dalaver H.

Khashab, Niveen M.

KAUST Department
Advanced Membranes and Porous Materials Research CenterBioscience Program
Chemical Science Program
Electron Microscopy
Imaging and Characterization Core Lab
Investment Fund
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Date
2015-09-29Online Publication Date
2015-09-29Print Publication Date
2015-11-18Permanent link to this record
http://hdl.handle.net/10754/578841
Metadata
Show full item recordAbstract
Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale –unlike most reported bridged silsesquioxane materials– with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.Citation
Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery 2015:150925103151004 ACS Applied Materials & InterfacesPublisher
American Chemical Society (ACS)PubMed ID
26406224Additional Links
http://pubs.acs.org/doi/10.1021/acsami.5b07365ae974a485f413a2113503eed53cd6c53
10.1021/acsami.5b07365
Scopus Count
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