Show simple item record

dc.contributor.authorKieler-Ferguson, Heidi M.
dc.contributor.authorFrechet, Jean
dc.contributor.authorSzoka, Francis C.
dc.date.accessioned2015-09-10T09:27:26Z
dc.date.available2015-09-10T09:27:26Z
dc.date.issued2013-01-17
dc.identifier.issn19395116
dc.identifier.pmid23335566
dc.identifier.doi10.1002/wnan.1209
dc.identifier.urihttp://hdl.handle.net/10754/577044
dc.description.abstractFor the past 40 years, liposomal and polymeric delivery vehicles have been studied as systems capable of modulating the cytotoxicity of small molecule chemotherapeutics, increasing tumor bearing animal survival times, and improving drug targeting. Although a number of macromolecular-drug conjugates have progressed to clinical trials, tuning drug release to maintain efficacy in conjunction with controlling drug toxicity has prevented the clinical adoption of many vehicles. In this article, we review the motivations for and approaches to polymer and liposomal delivery with regard to camptothecin and cisplatin delivery. WIREs Nanomed Nanobiotechnol 2013, 5:130-138. doi: 10.1002/wnan.1209 For further resources related to this article, please visit the WIREs website. Conflict of interest: Drs Kieler-Ferguson and Fréchet declare no conflicts of interest. Dr Szoka is the founder of a liposome drug delivery company that is not working on any of the compounds mentioned in this article. © 2013 Wiley Periodicals, Inc.
dc.description.sponsorshipPortions of this work were supported by NIH R01 grants GM061851 and EB002047.
dc.publisherWiley
dc.titleClinical developments of chemotherapeutic nanomedicines: Polymers and liposomes for delivery of camptothecins and platinum (II) drugs
dc.typeArticle
dc.contributor.departmentChemical Science Program
dc.contributor.departmentOffice of the VP
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
dc.contributor.institutionCollege of Chemistry, University of California, Berkeley, CA, United States
dc.contributor.institutionDepartment of Bioengineering, Therapeutic Sciences and Pharmaceutical Chemistry, University of California, San Francisco, CA, United States
kaust.personFrechet, Jean
dc.date.published-online2013-01-17
dc.date.published-print2013-03


This item appears in the following Collection(s)

Show simple item record