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dc.contributor.authorWalkey, Carl D.
dc.contributor.authorDas, Soumen C.
dc.contributor.authorSeal, Sudipta
dc.contributor.authorErlichman, Joseph S.
dc.contributor.authorHeckman, Karin L.
dc.contributor.authorGhibelli, Lina
dc.contributor.authorTraversa, Enrico
dc.contributor.authorMcGinnis, James F.
dc.contributor.authorSelf, William Thomas
dc.date.accessioned2015-08-25T06:18:21Z
dc.date.available2015-08-25T06:18:21Z
dc.date.issued2014-11-10
dc.identifier.issn20518153
dc.identifier.pmid26207185
dc.identifier.doi10.1039/c4en00138a
dc.identifier.urihttp://hdl.handle.net/10754/575893
dc.description.abstractCerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the test tube, cell culture models and animal models of disease. However given the reactivity that is well established at the surface of these nanoparticles, the biological utilization of nanoceria as a therapeutic still poses many challenges. Moreover the form that these particles take in a biological environment, such as the changes that can occur due to a protein corona, are not well established. This review aims to summarize the existing literature on biological use of nanoceria, and to raise questions about what further study is needed to apply this interesting catalytic material to biomedical applications. These questions include: 1) How does preparation, exposure dose, route and experimental model influence the reported effects of nanoceria in animal studies? 2) What are the considerations to develop nanoceria as a therapeutic agent in regards to these parameters? 3) What biological targets of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are relevant to this targeting, and how do these properties also influence the safety of these nanomaterials?
dc.description.sponsorshipJFM work was supported by NIH NEI grant COBRE-P20 RR017703, P30-EY 12190, R21EY018306, R01EY18724, R01EY022111; National Science Foundation: CBET-0708172; Foundation Fighting Blindness.This article is a product of a workshop on nanoceria held November 2, 2013 at the Fess Parker Doubletree Resort, Santa Barbara, CA, made possible by financial support from the Sustainable Nanotechnology Organization, The Tracy Farmer Institute for Sustainability and the Environment, the Department of Pharmaceutical Sciences, Associate Dean of Research of the College of Pharmacy and Office of the Vice President for Research, University of Kentucky.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleCatalytic properties and biomedical applications of cerium oxide nanoparticles
dc.typeArticle
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.contributor.departmentMaterials Science and Engineering Program
dc.contributor.departmentKAUST Solar Center (KSC)
dc.contributor.departmentMaterials for Energy Conversion and Storage (MECS) Lab
dc.identifier.journalEnviron. Sci.: Nano
dc.contributor.institutionIntegrated Nanotechnology and Biomedical Sciences Laboratory, University of Toronto, Terrence Donnelly Building 160 College St.Toronto, ON, Canada
dc.contributor.institutionAdvanced Materials Processing and Analysis Centre, Nanoscience Technology Center, University of Central FloridaOrlando, FL, United States
dc.contributor.institutionDepartment of Biology, St. Lawrence University, Johnson Hall of Science, 23 Romoda DriveCanton, NY, United States
dc.contributor.institutionDepartment of Biology, Università di Roma Tor Vergata, Via Della Ricerca ScientificaRoma, Italy
dc.contributor.institutionDean A. McGee Eye Institute, Department of Ophthalmology, 608 Stanton L. Young, Blvd.Oklahoma City, OK, United States
dc.contributor.institutionBurnett School of Biomedical Science, College of Medicine, University of Central FloridaOrlando, FL, United States
kaust.personTraversa, Enrico


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