Catalytic properties and biomedical applications of cerium oxide nanoparticles

Abstract
Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the test tube, cell culture models and animal models of disease. However given the reactivity that is well established at the surface of these nanoparticles, the biological utilization of nanoceria as a therapeutic still poses many challenges. Moreover the form that these particles take in a biological environment, such as the changes that can occur due to a protein corona, are not well established. This review aims to summarize the existing literature on biological use of nanoceria, and to raise questions about what further study is needed to apply this interesting catalytic material to biomedical applications. These questions include: 1) How does preparation, exposure dose, route and experimental model influence the reported effects of nanoceria in animal studies? 2) What are the considerations to develop nanoceria as a therapeutic agent in regards to these parameters? 3) What biological targets of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are relevant to this targeting, and how do these properties also influence the safety of these nanomaterials?

Citation
Walkey, C., Das, S., Seal, S., Erlichman, J., Heckman, K., Ghibelli, L., … Self, W. T. (2015). Catalytic properties and biomedical applications of cerium oxide nanoparticles. Environmental Science: Nano, 2(1), 33–53. doi:10.1039/c4en00138a

Acknowledgements
JFM work was supported by NIH NEI grant COBRE-P20 RR017703, P30-EY 12190, R21EY018306, R01EY18724, R01EY022111; National Science Foundation: CBET-0708172; Foundation Fighting Blindness.This article is a product of a workshop on nanoceria held November 2, 2013 at the Fess Parker Doubletree Resort, Santa Barbara, CA, made possible by financial support from the Sustainable Nanotechnology Organization, The Tracy Farmer Institute for Sustainability and the Environment, the Department of Pharmaceutical Sciences, Associate Dean of Research of the College of Pharmacy and Office of the Vice President for Research, University of Kentucky.

Publisher
Royal Society of Chemistry (RSC)

Journal
Environmental Science: Nano

DOI
10.1039/c4en00138a

PubMed ID
26207185

Additional Links
http://europepmc.org/articles/pmc4508017?pdf=render

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