An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man
Type
ArticleAuthors
Ravasi, Timothy
Suzuki, Harukazu
Cannistraci, Carlo
Katayama, Shintaro
Bajic, Vladimir B.

Tan, Kai
Akalin, Altuna
Schmeier, Sebastian

Kanamori-Katayama, Mutsumi
Bertin, Nicolas
Carninci, Piero
Daub, Carsten O.
Forrest, Alistair R.R.
Gough, Julian
Grimmond, Sean
Han, Jung-Hoon
Hashimoto, Takehiro
Hide, Winston
Hofmann, Oliver
Kamburov, Atanas
Kaur, Mandeep
Kawaji, Hideya

Kubosaki, Atsutaka
Lassmann, Timo
van Nimwegen, Erik
MacPherson, Cameron Ross
Ogawa, Chihiro
Radovanovic, Aleksandar
Schwartz, Ariel
Teasdale, Rohan D.
Tegnér, Jesper
Lenhard, Boris
Teichmann, Sarah A.
Arakawa, Takahiro
Ninomiya, Noriko
Murakami, Kayoko
Tagami, Michihira
Fukuda, Shiro
Imamura, Kengo
Kai, Chikatoshi
Ishihara, Ryoko
Kitazume, Yayoi
Kawai, Jun
Hume, David A.
Ideker, Trey
Hayashizaki, Yoshihide
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Computational Bioscience Research Center (CBRC)
Bioscience Program
Integrative Systems Biology Lab
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Applied Mathematics and Computational Science Program
Computational Bioscience Research Center (CBRC)
Applied Mathematics and Computational Science Program
Date
2010-03-05Embargo End Date
2011-03-05Permanent link to this record
http://hdl.handle.net/10754/575669
Metadata
Show full item recordAbstract
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution.Citation
Ravasi, T., Suzuki, H., Cannistraci, C. V., Katayama, S., Bajic, V. B., Tan, K., … Hayashizaki, Y. (2010). An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man. Cell, 140(5), 744–752. doi:10.1016/j.cell.2010.01.044Sponsors
The work for the RIKEN Omics Science Center was supported by grants from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) through the Genome Network Project and for the RIKEN Omics Science Center (YH, Principal Investigator). Members of the FANTOM Consortium were supported by grant MH062261 from the US National Institute of Mental Health (TR, KT, TI), the King Abdullah University of Science and Technology (TR, VBB), the Max Planck Society for the Advancement of Science (AK), the SA National Bioinformatics Network (SS, AR, VBB, WAH), the Claude Leon Foundation (MK), a CJ Martin Fellowship from the Australian NHMRC (ARRF), and the Scuola Interpolitecnica di Dottorato (CVC). The authors gratefully acknowledge S. Choi for critical feedback on the manuscript.Publisher
Elsevier BVJournal
CellAdditional Links
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836267ae974a485f413a2113503eed53cd6c53
10.1016/j.cell.2010.01.044