• Login
    View Item 
    •   Home
    • Research
    • Articles
    • View Item
    •   Home
    • Research
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguideTheses and Dissertations LibguideSubmit an Item

    Statistics

    Display statistics

    An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    nihms177825.pdf
    Size:
    2.204Mb
    Format:
    PDF
    Description:
    Accepted manuscript
    Download
    Type
    Article
    Authors
    Ravasi, Timothy cc
    Suzuki, Harukazu
    Cannistraci, Carlo
    Katayama, Shintaro
    Bajic, Vladimir B. cc
    Tan, Kai
    Akalin, Altuna
    Schmeier, Sebastian cc
    Kanamori-Katayama, Mutsumi
    Bertin, Nicolas
    Carninci, Piero
    Daub, Carsten O.
    Forrest, Alistair R.R.
    Gough, Julian
    Grimmond, Sean
    Han, Jung-Hoon
    Hashimoto, Takehiro
    Hide, Winston
    Hofmann, Oliver
    Kamburov, Atanas
    Kaur, Mandeep
    Kawaji, Hideya cc
    Kubosaki, Atsutaka
    Lassmann, Timo
    van Nimwegen, Erik
    MacPherson, Cameron Ross
    Ogawa, Chihiro
    Radovanovic, Aleksandar
    Schwartz, Ariel
    Teasdale, Rohan D.
    Tegnér, Jesper
    Lenhard, Boris
    Teichmann, Sarah A.
    Arakawa, Takahiro
    Ninomiya, Noriko
    Murakami, Kayoko
    Tagami, Michihira
    Fukuda, Shiro
    Imamura, Kengo
    Kai, Chikatoshi
    Ishihara, Ryoko
    Kitazume, Yayoi
    Kawai, Jun
    Hume, David A.
    Ideker, Trey
    Hayashizaki, Yoshihide
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Bioscience Program
    Integrative Systems Biology Lab
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Applied Mathematics and Computational Science Program
    Computational Bioscience Research Center (CBRC)
    Applied Mathematics and Computational Science Program
    Date
    2010-03-05
    Embargo End Date
    2011-03-05
    Permanent link to this record
    http://hdl.handle.net/10754/575669
    
    Metadata
    Show full item record
    Abstract
    Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution.
    Citation
    Ravasi, T., Suzuki, H., Cannistraci, C. V., Katayama, S., Bajic, V. B., Tan, K., … Hayashizaki, Y. (2010). An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man. Cell, 140(5), 744–752. doi:10.1016/j.cell.2010.01.044
    Sponsors
    The work for the RIKEN Omics Science Center was supported by grants from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) through the Genome Network Project and for the RIKEN Omics Science Center (YH, Principal Investigator). Members of the FANTOM Consortium were supported by grant MH062261 from the US National Institute of Mental Health (TR, KT, TI), the King Abdullah University of Science and Technology (TR, VBB), the Max Planck Society for the Advancement of Science (AK), the SA National Bioinformatics Network (SS, AR, VBB, WAH), the Claude Leon Foundation (MK), a CJ Martin Fellowship from the Australian NHMRC (ARRF), and the Scuola Interpolitecnica di Dottorato (CVC). The authors gratefully acknowledge S. Choi for critical feedback on the manuscript.
    Publisher
    Elsevier BV
    Journal
    Cell
    DOI
    10.1016/j.cell.2010.01.044
    Additional Links
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836267
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cell.2010.01.044
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Red Sea Research Center (RSRC); Bioscience Program; Applied Mathematics and Computational Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

    entitlement

     
    DSpace software copyright © 2002-2022  DuraSpace
    Quick Guide | Contact Us | KAUST University Library
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.