KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
KAUST Catalysis Center (KCC)
KAUST Global Partnership Program
Water Desalination and Reuse Research Center (WDRC)
Permanent link to this recordhttp://hdl.handle.net/10754/575668
MetadataShow full item record
AbstractBiofouling causes huge economic loss and a recent global ban on organotin compounds as antifouling agents has increased the need for safe and effective antifouling compounds. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces strain obtained from deep-sea sediments. Antifouling activities of these five compounds and four other structurally-related compounds isolated from a North Sea Streptomyces strain against major fouling organisms were compared to probe structure-activity relationships of compounds. The functional moiety responsible for antifouling activity lies in the 2-furanone ring and that the lipophilicity of compounds substantially affects their antifouling activities. Based on these findings, a compound with a straight alkyl side-chain was synthesized and proved itself as a very effective non-toxic, anti-larval settlement agent against three major fouling organisms. The strong antifouling activity, relatively low toxicity, and simple structures of these compounds make them promising candidates for new antifouling additives. © 2009 Elsevier Ltd. All rights reserved.
SponsorsThis work was supported by a Grant from China Ocean Mineral Resources Research and Development Association (COMRRDA06/07.Sc02), a RGC Grant (HKUST6418/06M) from the Hong Kong SAR, and a Grant from the King Abdullah University of Science & Technology Global Special Academic Partnership Program (KAUST003-CML.07/08) to PY Qjan.
- Structural optimization and evaluation of butenolides as potent antifouling agents: modification of the side chain affects the biological activities of compounds.
- Authors: Li Y, Zhang F, Xu Y, Matsumura K, Han Z, Liu L, Lin W, Jia Y, Qian PY
- Issue date: 2012
- Antifouling diketopiperazines produced by a deep-sea bacterium, Streptomyces fungicidicus.
- Authors: Li X, Dobretsov S, Xu Y, Xiao X, Hung OS, Qian PY
- Issue date: 2006
- Antibacterial and antilarval activity of deep-sea bacteria from sediments of the West Pacific Ocean.
- Authors: Xu Y, Miao L, Li XC, Xiao X, Qian PY
- Issue date: 2007
- Antifouling potentials of eight deep-sea-derived fungi from the South China Sea.
- Authors: Zhang XY, Xu XY, Peng J, Ma CF, Nong XH, Bao J, Zhang GZ, Qi SH
- Issue date: 2014 Apr
- Potent Antifouling Marine Dihydroquinolin-2(1H)-one-Containing Alkaloids from the Gorgonian Coral-Derived Fungus Scopulariopsis sp.
- Authors: Shao CL, Xu RF, Wang CY, Qian PY, Wang KL, Wei MY
- Issue date: 2015 Aug