Synthesis of Fluoroalkoxy Substituted Arylboronic Esters by Iridium-Catalyzed Aromatic C–H Borylation
Type
ArticleAuthors
Batool, FarhatParveen, Shehla
Emwas, Abdul-Hamid M.
Sioud, Salim
Gao, Xin

Munawar, Munawar A.
Chotana, Ghayoor A.
KAUST Department
Advanced Nanofabrication, Imaging and Characterization Core LabComputational Bioscience Research Center (CBRC)
Computer Science Program
Computer Science Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Core Labs
NMR
Organics
Structural and Functional Bioinformatics Group
Date
2015-08-17Online Publication Date
2015-08-17Print Publication Date
2015-09-04Permanent link to this record
http://hdl.handle.net/10754/575662
Metadata
Show full item recordAbstract
The preparation of fluoroalkoxy arylboronic esters by iridium-catalyzed aromatic C–H borylation is described. The fluoroalkoxy groups employed include trifluoromethoxy, difluoromethoxy, 1,1,2,2-tetrafluoroethoxy, and 2,2-difluoro-1,3-benzodioxole. The borylation reactions were carried out neat without the use of a glovebox or Schlenk line. The regioselectivities available through the iridium-catalyzed C–H borylation are complementary to those obtained by the electrophilic aromatic substitution reactions of fluoroalkoxy arenes. Fluoroalkoxy arylboronic esters can serve as versatile building blocks.Citation
Batool, F., Parveen, S., Emwas, A.-H., Sioud, S., Gao, X., Munawar, M. A., & Chotana, G. A. (2015). Synthesis of Fluoroalkoxy Substituted Arylboronic Esters by Iridium-Catalyzed Aromatic C–H Borylation. Organic Letters, 17(17), 4256–4259. doi:10.1021/acs.orglett.5b02050Publisher
American Chemical Society (ACS)Journal
Organic LettersPubMed ID
26278016ae974a485f413a2113503eed53cd6c53
10.1021/acs.orglett.5b02050
Scopus Count
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