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dc.contributor.authorDeng, Lin
dc.contributor.authorLi, Qiujin
dc.contributor.authorYang, Yang
dc.contributor.authorOmar, Haneen
dc.contributor.authorTang, Naijun
dc.contributor.authorZhang, Jianfei
dc.contributor.authorNie, Zhihong
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2015-08-24T08:35:15Z
dc.date.available2015-08-24T08:35:15Z
dc.date.issued2015-08-13
dc.identifier.issn0947-6539
dc.identifier.pmid26275063
dc.identifier.doi10.1002/chem.201502522
dc.identifier.urihttp://hdl.handle.net/10754/575660
dc.description.abstractGraphene oxide-wrapped gold nanorods (GO@AuNRs) offer efficient drug delivery as well as NIR laser photothermal therapy (PTT) in vitro and in vivo. However, no real-time observation of drug release has been reported to better understand the synergy of chemotherapy and PTT. Herein, surface-enhance Raman spectroscopy (SERS) is employed to guide chemo-photothermal cancer therapy by a two-step mechanism. In the presence of GO as an internal standard, SERS signals of DOX (doxorubicin) loaded onto GO@AuNRs are found to be pH-responsive. Both DOX and GO show strong SERS signals before the DOX@GO@AuNRs are endocytic. However, when the DOX@GO@AuNRs enter acidic microenvironments such as endosomes and/or lysosomes, the DOX signals start decreasing while the GO signals remain the same. This plasmonic antenna could be used to identify the appropriate time to apply the PTT laser during chemo-photothermal therapy.
dc.publisherWiley
dc.title“Two-Step” Raman Imaging Technique To Guide Chemo-Photothermal Cancer Therapy
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentChemical Science Program
dc.contributor.departmentChemical Science Program
dc.contributor.departmentCore Labs
dc.contributor.departmentPhysical Characterization
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalChemistry - A European Journal
dc.contributor.institutionSchool of Textiles, Tianjin Polytechnic University, Key Laboratory of Advanced Textile Composites, Ministry of Education, Tianjin 300387 (P. R. China)
dc.contributor.institutionDepartment of Occupational & Environmental Health, Tianjin Medical University, Tianjin 300070 (P. R. China)
dc.contributor.institutionDepartment of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 (USA)
kaust.personDeng, Lin
kaust.personYang, Yang
kaust.personKhashab, Niveen M.
kaust.personLi, Qiujin
kaust.personOmar, Haneen
dc.date.published-online2015-08-13
dc.date.published-print2015-11-23


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