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    Hepatic Proteomic Responses in Marine Medaka ( Oryzias melastigma ) Chronically Exposed to Antifouling Compound Butenolide [5-octylfuran-2(5H)-one] or 4,5-Dichloro-2- N -Octyl-4-Isothiazolin-3-One (DCOIT)

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    Type
    Article
    Authors
    Chen, Lianguo
    Sun, Jin
    Zhang, Huoming cc
    Au, Doris W. T.
    Lam, Paul K. S.
    Zhang, Weipeng
    Bajic, Vladimir B. cc
    Qiu, Jian-Wen cc
    Qian, Pei-Yuan cc
    KAUST Department
    Bioscience Core Lab
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Applied Mathematics and Computational Science Program
    Computational Bioscience Research Center (CBRC)
    Core Labs
    Date
    2015-01-16
    Online Publication Date
    2015-01-16
    Print Publication Date
    2015-02-03
    Permanent link to this record
    http://hdl.handle.net/10754/575639
    
    Metadata
    Show full item record
    Abstract
    The pollution of antifoulant SeaNine 211, with 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) as active ingredient, in coastal environment raises concerns on its adverse effects, including endocrine disruption and impairment of reproductive function in marine organisms. In the present study, we investigated the hepatic protein expression profiles of both male and female marine medaka (Oryzias melastigma) exposed to low concentrations of DCOIT at 2.55 mu g/L (0.009 mu M) or butenolide, a promising antifouling agent, at 2.31 mu g/L (0.012 mu M) for 28 days. The results showed that proteins involved in phase I (CYP450 enzyme) metabolism, phase II (UDPGT and GST) conjugation as well as mobilization of retinoid storage, an effective nonenzymatic antioxidant, were consistently up-regulated, possibly facilitating the accelerated detoxification of butenolide. Increased synthesis of bile acid would promote the immediate excretion of butenolide metabolites. Activation of fatty acid beta-oxidation and ATP synthesis were consistent with elevated energy consumption for butenolide degradation and excretion. However, DCOIT did not significantly affect the detoxification system of male medaka, but induced a marked increase of vitellogenin (VTG) by 2.3-fold in the liver of male medaka, suggesting that there is estrogenic activity of DCOIT in endocrine disruption. Overall, this study identified the molecular mechanisms and provided sensitive biomarkers characteristic of butenolide and DCOIT in the liver of marine medaka. The low concentrations of butenolide and DCOIT used in the exposure regimes highlight the needs for systematic evaluation of their environmental risk. In addition, the potent estrogenic activity of DCOIT should be considered in the continued applications of SeaNine 211.
    Citation
    Chen, L., Sun, J., Zhang, H., Au, D. W. T., Lam, P. K. S., Zhang, W., … Qian, P.-Y. (2015). Hepatic Proteomic Responses in Marine Medaka (Oryzias melastigma) Chronically Exposed to Antifouling Compound Butenolide [5-octylfuran-2(5H)-one] or 4,5-Dichloro-2-N-Octyl-4-Isothiazolin-3-One (DCOIT). Environmental Science & Technology, 49(3), 1851–1859. doi:10.1021/es5046748
    Sponsors
    This study was generously supported by a grant (DY125-15-T-02) from China Ocean Mineral Resources Research and Development Association, and an award (SA-C0040/UK-C0016) from the King Abdullah University of Science and Technology to P.-Y.Q.
    Publisher
    American Chemical Society (ACS)
    Journal
    Environmental Science & Technology
    DOI
    10.1021/es5046748
    ae974a485f413a2113503eed53cd6c53
    10.1021/es5046748
    Scopus Count
    Collections
    Articles; Applied Mathematics and Computational Science Program; Computational Bioscience Research Center (CBRC); Bioscience Core Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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