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dc.contributor.authorMarquet, Pierre
dc.contributor.authorDepeursinge, Christian D.
dc.contributor.authorMagistretti, Pierre J.
dc.date.accessioned2015-08-24T08:33:21Z
dc.date.available2015-08-24T08:33:21Z
dc.date.issued2013-07-11
dc.identifier.issn15239829
dc.identifier.pmid23662777
dc.identifier.doi10.1146/annurev-bioeng-071812-152356
dc.identifier.urihttp://hdl.handle.net/10754/575578
dc.description.abstractIn this review, we summarize how the new concept of digital optics applied to the field of holographic microscopy has allowed the development of a reliable and flexible digital holographic quantitative phase microscopy (DH-QPM) technique at the nanoscale particularly suitable for cell imaging. Particular emphasis is placed on the original biological ormation provided by the quantitative phase signal. We present the most relevant DH-QPM applications in the field of cell biology, including automated cell counts, recognition, classification, three-dimensional tracking, discrimination between physiological and pathophysiological states, and the study of cell membrane fluctuations at the nanoscale. In the last part, original results show how DH-QPM can address two important issues in the field of neurobiology, namely, multiple-site optical recording of neuronal activity and noninvasive visualization of dendritic spine dynamics resulting from a full digital holographic microscopy tomographic approach. Copyright © 2013 by Annual Reviews.
dc.publisherAnnual Reviews
dc.subjectcell imaging
dc.subjectdendritic spines
dc.subjectdiffraction tomography
dc.subjectdigital holographic microscopy
dc.subjectneuronal activities
dc.subjectquantitative phase microscopy
dc.titleExploring neural cell dynamics with digital holographic microscopy
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalAnnual Review of Biomedical Engineering
dc.contributor.institutionCentre de Neurosciences Psychiatriques, Centre Hospitalier Universitaire Vaudois (CHUV), Département de Psychiatrie, Site de Cery, CH-1008 Prilly/Lausanne, Switzerland
dc.contributor.institutionBrain Mind Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
dc.contributor.institutionInstitute of Microengineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
kaust.personMagistretti, Pierre J.


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