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dc.contributor.authorKuhn, Paul-Steffen
dc.contributor.authorCremer, Laura
dc.contributor.authorGavriluta, Anatolie
dc.contributor.authorJovanović, Katarina K.
dc.contributor.authorFilipović, Lana
dc.contributor.authorHummer, Alfred A.
dc.contributor.authorBüchel, Gabriel E.
dc.contributor.authorDojčinović, Biljana P.
dc.contributor.authorMeier, Samuel M.
dc.contributor.authorRompel, Annette
dc.contributor.authorRadulović, Siniša
dc.contributor.authorTommasino, Jean Bernard
dc.contributor.authorLuneau, Dominique
dc.contributor.authorArion, Vladimir B.
dc.date.accessioned2015-08-13T11:30:13Z
dc.date.available2015-08-13T11:30:13Z
dc.date.issued2015-08-10
dc.identifier.citationHeteropentanuclear Oxalato-Bridged nd–4f (n=4, 5) Metal Complexes with NO Ligand: Synthesis, Crystal Structures, Aqueous Stability and Antiproliferative Activity 2015: Chemistry - A European Journal
dc.identifier.issn09476539
dc.identifier.pmid26260662
dc.identifier.doi10.1002/chem.201502026
dc.identifier.urihttp://hdl.handle.net/10754/566967
dc.description.abstractA series of heteropentanuclear oxalate-bridged Ru(NO)-Ln (4d–4f) metal complexes of the general formula (nBu4N)5[Ln{RuCl3(μ-ox)(NO)}4], where Ln=Y (2), Gd (3), Tb (4), Dy (5) and ox=oxalate anion, were obtained by treatment of (nBu4N)2[RuCl3(ox)(NO)] (1) with the respective lanthanide salt in 4:1 molar ratio. The compounds were characterized by elemental analysis, IR spectroscopy, electrospray ionization (ESI) mass spectrometry, while 1, 2, and 5 were in addition analyzed by X-ray crystallography, 1 by Ru K-edge XAS and 1 and 2 by 13C NMR spectroscopy. X-ray diffraction showed that in 2 and 5 four complex anions [RuCl3(ox)(NO)]2− are coordinated to YIII and DyIII, respectively, with formation of [Ln{RuCl3(μ-ox)(NO)}4]5− (Ln=Y, Dy). While YIII is eight-coordinate in 2, DyIII is nine-coordinate in 5, with an additional coordination of an EtOH molecule. The negative charge is counterbalanced by five nBu4N+ ions present in the crystal structure. The stability of complexes 2 and 5 in aqueous medium was monitored by UV/Vis spectroscopy. The antiproliferative activity of ruthenium-lanthanide complexes 2–5 were assayed in two human cancer cell lines (HeLa and A549) and in a noncancerous cell line (MRC-5) and compared with those obtained for the previously reported Os(NO)-Ln (5d–4f) analogues (nBu4N)5[Ln{OsCl3(ox)(NO)}4] (Ln=Y (6), Gd (7), Tb (8), Dy (9)). Complexes 2–5 were found to be slightly more active than 1 in inhibiting the proliferation of HeLa and A549 cells, and significantly more cytotoxic than 5d–4f metal complexes 6–9 in terms of IC50 values. The highest antiproliferative activity with IC50 values of 20.0 and 22.4 μM was found for 4 in HeLa and A549 cell lines, respectively. These cytotoxicity results are in accord with the presented ICP-MS data, indicating five- to eightfold greater accumulation of ruthenium versus osmium in human A549 cancer cells.
dc.language.isoen
dc.publisherWiley
dc.relation.urlhttp://doi.wiley.com/10.1002/chem.201502026
dc.rightsThis is the peer reviewed version of the following article: Kuhn, P.-S., Cremer, L., Gavriluta, A., Jovanović, K. K., Filipović, L., Hummer, A. A., Büchel, G. E., Dojčinović, B. P., Meier, S. M., Rompel, A., Radulović, S., Tommasino, J. B., Luneau, D. and Arion, V. B. (2015), Heteropentanuclear Oxalato-Bridged nd–4f (n=4, 5) Metal Complexes with NO Ligand: Synthesis, Crystal Structures, Aqueous Stability and Antiproliferative Activity. Chem. Eur. J.. doi: 10.1002/chem.201502026, which has been published in final form at http://doi.wiley.com/10.1002/chem.201502026. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
dc.subjectantitumor agents
dc.subjectlanthanide
dc.subjectnitrosyl
dc.subjectosmium
dc.subjectruthenium
dc.titleHeteropentanuclear Oxalato-Bridged nd–4f (n=4, 5) Metal Complexes with NO Ligand: Synthesis, Crystal Structures, Aqueous Stability and Antiproliferative Activity
dc.typeArticle
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalChemistry - A European Journal
dc.eprint.versionPost-print
dc.contributor.institutionUniversity of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Währinger Strasse 42, 1090 Vienna (Austria)
dc.contributor.institutionUniversité Claude Bernard Lyon 1, Laboratoire des Multimatériaux et Interfaces (UMR 5615), Campus de la Doua, 69622 Villeurbanne cedex (France)
dc.contributor.institutionInstitute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade (Serbia)
dc.contributor.institutionUniversität Wien, Fakultät für Chemie, Institut für Biophysikalische Chemie, Althanstraße 14, 1090 Wien (Austria)
dc.contributor.institutionFaculty of Chemistry, Institute of Analytical Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna (Austria)
dc.contributor.institutionUniversity of Belgrade, Institute of Chemistry, Technology and Metallurgy, Center of Chemistry, Studentski trg 12-16, Belgrade (Serbia)
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personBüchel, Gabriel E.
dc.relation.issupplementedbyDOI:10.5517/cc1j1ym4
dc.relation.issupplementedbyDOI:10.5517/cc1j1yn5
dc.relation.issupplementedbyDOI:10.5517/cc10y7y4
refterms.dateFOA2016-08-10T00:00:00Z
display.relations<b> Is Supplemented By:</b> <br/> <ul><li><i>[Dataset]</i> <br/> Kuhn, P.-S., Cremer, L., Gavriluta, A., Jovanović, K. K., Filipović, L., Hummer, A. A., … Arion, V. B. (2015). CCDC 1402056: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc1j1ym4. DOI: <a href="https://doi.org/10.5517/cc1j1ym4">10.5517/cc1j1ym4</a> HANDLE: <a href="http://hdl.handle.net/10754/624431">10754/624431</a></li><li><i>[Dataset]</i> <br/> Kuhn, P.-S., Cremer, L., Gavriluta, A., Jovanović, K. K., Filipović, L., Hummer, A. A., … Arion, V. B. (2015). CCDC 1402057: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc1j1yn5. DOI: <a href="https://doi.org/10.5517/cc1j1yn5">10.5517/cc1j1yn5</a> HANDLE: <a href="http://hdl.handle.net/10754/624432">10754/624432</a></li><li><i>[Dataset]</i> <br/> Kuhn, P.-S., Cremer, L., Gavriluta, A., Jovanović, K. K., Filipović, L., Hummer, A. A., … Arion, V. B. (2015). CCDC 951636: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc10y7y4. DOI: <a href="https://doi.org/10.5517/cc10y7y4">10.5517/cc10y7y4</a> HANDLE: <a href="http://hdl.handle.net/10754/624243">10754/624243</a></li></ul>
dc.date.published-online2015-08-10
dc.date.published-print2015-09-21


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