• Login
    View Item 
    •   Home
    • Research
    • Articles
    • View Item
    •   Home
    • Research
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguidePlumX LibguideSubmit an Item

    Statistics

    Display statistics

    Heteropentanuclear Oxalato-Bridged nd–4f (n=4, 5) Metal Complexes with NO Ligand: Synthesis, Crystal Structures, Aqueous Stability and Antiproliferative Activity

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Kuhn_et_al-2015-Chemistry_-_A_European_Journal.pdf
    Size:
    991.9Kb
    Format:
    PDF
    Description:
    Accepted Manuscript
    Download
    Thumbnail
    Name:
    chem_201502026_sm_miscellaneous_information.pdf
    Size:
    569.5Kb
    Format:
    PDF
    Description:
    Supplemental files
    Download
    Type
    Article
    Authors
    Kuhn, Paul-Steffen
    Cremer, Laura
    Gavriluta, Anatolie
    Jovanović, Katarina K.
    Filipović, Lana
    Hummer, Alfred A.
    Büchel, Gabriel E. cc
    Dojčinović, Biljana P.
    Meier, Samuel M.
    Rompel, Annette
    Radulović, Siniša
    Tommasino, Jean Bernard
    Luneau, Dominique
    Arion, Vladimir B.
    KAUST Department
    KAUST Catalysis Center (KCC)
    Physical Science and Engineering (PSE) Division
    Date
    2015-08-10
    Online Publication Date
    2015-08-10
    Print Publication Date
    2015-09-21
    Permanent link to this record
    http://hdl.handle.net/10754/566967
    
    Metadata
    Show full item record
    Abstract
    A series of heteropentanuclear oxalate-bridged Ru(NO)-Ln (4d–4f) metal complexes of the general formula (nBu4N)5[Ln{RuCl3(μ-ox)(NO)}4], where Ln=Y (2), Gd (3), Tb (4), Dy (5) and ox=oxalate anion, were obtained by treatment of (nBu4N)2[RuCl3(ox)(NO)] (1) with the respective lanthanide salt in 4:1 molar ratio. The compounds were characterized by elemental analysis, IR spectroscopy, electrospray ionization (ESI) mass spectrometry, while 1, 2, and 5 were in addition analyzed by X-ray crystallography, 1 by Ru K-edge XAS and 1 and 2 by 13C NMR spectroscopy. X-ray diffraction showed that in 2 and 5 four complex anions [RuCl3(ox)(NO)]2− are coordinated to YIII and DyIII, respectively, with formation of [Ln{RuCl3(μ-ox)(NO)}4]5− (Ln=Y, Dy). While YIII is eight-coordinate in 2, DyIII is nine-coordinate in 5, with an additional coordination of an EtOH molecule. The negative charge is counterbalanced by five nBu4N+ ions present in the crystal structure. The stability of complexes 2 and 5 in aqueous medium was monitored by UV/Vis spectroscopy. The antiproliferative activity of ruthenium-lanthanide complexes 2–5 were assayed in two human cancer cell lines (HeLa and A549) and in a noncancerous cell line (MRC-5) and compared with those obtained for the previously reported Os(NO)-Ln (5d–4f) analogues (nBu4N)5[Ln{OsCl3(ox)(NO)}4] (Ln=Y (6), Gd (7), Tb (8), Dy (9)). Complexes 2–5 were found to be slightly more active than 1 in inhibiting the proliferation of HeLa and A549 cells, and significantly more cytotoxic than 5d–4f metal complexes 6–9 in terms of IC50 values. The highest antiproliferative activity with IC50 values of 20.0 and 22.4 μM was found for 4 in HeLa and A549 cell lines, respectively. These cytotoxicity results are in accord with the presented ICP-MS data, indicating five- to eightfold greater accumulation of ruthenium versus osmium in human A549 cancer cells.
    Citation
    Heteropentanuclear Oxalato-Bridged nd–4f (n=4, 5) Metal Complexes with NO Ligand: Synthesis, Crystal Structures, Aqueous Stability and Antiproliferative Activity 2015: Chemistry - A European Journal
    Publisher
    Wiley
    Journal
    Chemistry - A European Journal
    DOI
    10.1002/chem.201502026
    PubMed ID
    26260662
    Additional Links
    http://doi.wiley.com/10.1002/chem.201502026
    Relations
    Is Supplemented By:
    • [Dataset]
      Kuhn, P.-S., Cremer, L., Gavriluta, A., Jovanović, K. K., Filipović, L., Hummer, A. A., … Arion, V. B. (2015). CCDC 1402056: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc1j1ym4. DOI: 10.5517/cc1j1ym4 HANDLE: 10754/624431
    • [Dataset]
      Kuhn, P.-S., Cremer, L., Gavriluta, A., Jovanović, K. K., Filipović, L., Hummer, A. A., … Arion, V. B. (2015). CCDC 1402057: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc1j1yn5. DOI: 10.5517/cc1j1yn5 HANDLE: 10754/624432
    • [Dataset]
      Kuhn, P.-S., Cremer, L., Gavriluta, A., Jovanović, K. K., Filipović, L., Hummer, A. A., … Arion, V. B. (2015). CCDC 951636: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/cc10y7y4. DOI: 10.5517/cc10y7y4 HANDLE: 10754/624243
    ae974a485f413a2113503eed53cd6c53
    10.1002/chem.201502026
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; KAUST Catalysis Center (KCC)

    entitlement

    Related articles

    • Ruthenium-nitrosyl complexes with glycine, L-alanine, L-valine, L-proline, D-proline, L-serine, L-threonine, and L-tyrosine: synthesis, X-ray diffraction structures, spectroscopic and electrochemical properties, and antiproliferative activity.
    • Authors: Rathgeb A, Böhm A, Novak MS, Gavriluta A, Dömötör O, Tommasino JB, Enyedy EA, Shova S, Meier S, Jakupec MA, Luneau D, Arion VB
    • Issue date: 2014 Mar 3
    • Osmium(III) analogues of KP1019: electrochemical and chemical synthesis, spectroscopic characterization, X-ray crystallography, hydrolytic stability, and antiproliferative activity.
    • Authors: Kuhn PS, Büchel GE, Jovanović KK, Filipović L, Radulović S, Rapta P, Arion VB
    • Issue date: 2014 Oct 20
    • Striking difference in antiproliferative activity of ruthenium- and osmium-nitrosyl complexes with azole heterocycles.
    • Authors: Büchel GE, Gavriluta A, Novak M, Meier SM, Jakupec MA, Cuzan O, Turta C, Tommasino JB, Jeanneau E, Novitchi G, Luneau D, Arion VB
    • Issue date: 2013 Jun 3
    • Synthesis, X-ray structure, physicochemical properties and anticancer activity of mer and fac Ru(iii) triphenylphosphine complexes with a benzothiazole derivative as a co-ligand.
    • Authors: Richert M, Walczyk M, Cieślak MJ, Kaźmierczak-Barańska J, Królewska-Golińska K, Wrzeszcz G, Muzioł T, Biniak S
    • Issue date: 2019 Jul 16
    • Syntheses, structures, and magnetic properties of acetato- and diphenolato-bridged 3d-4f binuclear complexes [M(3-MeOsaltn)(MeOH)x(ac)Ln(hfac)2] (M = Zn(II), Cu(II), Ni(II), Co(II); Ln = La(III), Gd(III), Tb(III), Dy(III); 3-MeOsaltn = N,N'-bis(3-methoxy-2-oxybenzylidene)-1,3-propanediaminato; ac = acetato; hfac = hexafluoroacetylacetonato; x = 0 or 1).
    • Authors: Towatari M, Nishi K, Fujinami T, Matsumoto N, Sunatsuki Y, Kojima M, Mochida N, Ishida T, Re N, Mrozinski J
    • Issue date: 2013 May 20
    DSpace software copyright © 2002-2021  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.