KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Desert Agriculture Initiative
Online Publication Date2013-10-31
Print Publication Date2014-01-08
Permanent link to this recordhttp://hdl.handle.net/10754/566130
MetadataShow full item record
AbstractCarotenoid synthesis is based on the analysis of the phenotype of several mutant strains of tomato lacking carotenoid synthetic genes. Carotenoids are tetraterpenes derived through the condensation of the five-carbon (C5) universal isoprenoid precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). A recently developed concept that could explain the role of the poly-cis pathway in carotenoid synthesis is that the intermediates of this pathway have additional physiological roles that extend beyond serving as precursors of lycopene. This concept is based on the analysis of the phenotype of several mutant strains of tomato lacking carotenoid synthetic genes. The feedback regulation of early carotenoid synthetic genes in response to a block in upstream metabolism represents a paradigm shift in our understanding of the mechanism and regulation of carotenoid synthesis and of metabolic regulation in general. The molecular details of a signaling pathway that regulates carotenogenesis in response to the levels of carotenoid precursors are still unclear.
SponsorsThe carotenoid and retinoid research in the Moise lab is supported by startup funds provided by the Department of Pharmacology and Toxicology, by a grant from the National Institutes of Health Grants 5P20RR017708-10, and a Graduate Research Fellowship from the University of Kansas. The carotenoid research in the Al-Babili lab was supported by the Deutsche Forschungsgemeinschaft (DFG) grant number AL 892/1-4. The carotenoid research in the Wurtzel lab has been funded by the U.S. National Institutes of Health, Rockefeller Foundation International Rice Biotechnology Program, McKnight Foundation, American Cancer Society, U.S. National Science Foundation, United States Department of Agriculture, PSC-CUNY, and New York State. We thank Dr. Brian Blagg, Medicinal Chemistry, University of Kansas, for critical comments and important suggestions on the manuscript. We thank Dr. Alfonso Prado-Cabrero, Center for Desert Agriculture (CDA), King Abdullah University of Science and Technology, for his contributions and suggestions for the illustration used for Cover Art and the Table of Contents.
PublisherAmerican Chemical Society (ACS)
PubMed Central IDPMC3898671
- Developments in carotenoid biochemistry over 40 years. The third Morton lecture.
- Authors: Goodwin TW
- Issue date: 1983 Oct
- Biosynthesis of carotenoid glucoside esters in Myxococcus fulvus (Myxobacterales): inhibition by nicotine and carotenoid turnover.
- Authors: Kleinig H, Reichenbach H
- Issue date: 1973 May 24
- Biosynthesis of carotenoids and plant triterpenes.
- Authors: Goodwin TW
- Issue date: 1971 Jul
- Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis.
- Authors: Henriksson LM, Unge T, Carlsson J, Aqvist J, Mowbray SL, Jones TA
- Issue date: 2007 Jul 6
- Aerobic conditions increase isoprenoid biosynthesis pathway gene expression levels for carotenoid production in Enterococcus gilvus.
- Authors: Hagi T, Kobayashi M, Nomura M
- Issue date: 2015 Jun