Show simple item record

dc.contributor.authorHe, Xinjian
dc.contributor.authorChen, Taiping
dc.contributor.authorZhu, Jian-Kang
dc.date.accessioned2015-08-12T08:59:57Z
dc.date.available2015-08-12T08:59:57Z
dc.date.issued2011-02-15
dc.identifier.issn10010602
dc.identifier.pmid21321601
dc.identifier.doi10.1038/cr.2011.23
dc.identifier.urihttp://hdl.handle.net/10754/566024
dc.description.abstractDNA methylation is an important epigenetic mark involved in diverse biological processes. In plants, DNA methylation can be established through the RNA-directed DNA methylation pathway, an RNA interference pathway for transcriptional gene silencing (TGS), which requires 24-nt small interfering RNAs. In mammals, de novo DNA methylation occurs primarily at two developmental stages: during early embryogenesis and during gametogenesis. While it is not clear whether establishment of DNA methylation patterns in mammals involves RNA interference in general, de novo DNA methylation and suppression of transposons in germ cells require 24-32-nt piwi-interacting small RNAs. DNA methylation status is dynamically regulated by DNA methylation and demethylation reactions. In plants, active DNA demethylation relies on the repressor of silencing 1 family of bifunctional DNA glycosylases, which remove the 5-methylcytosine base and then cleave the DNA backbone at the abasic site, initiating a base excision repair (BER) pathway. In animals, multiple mechanisms of active DNA demethylation have been proposed, including a deaminase- and DNA glycosylase-initiated BER pathway. New information concerning the effects of various histone modifications on the establishment and maintenance of DNA methylation has broadened our understanding of the regulation of DNA methylation. The function of DNA methylation in plants and animals is also discussed in this review. © 2011 IBCB, SIBS, CAS All rights reserved.
dc.description.sponsorshipThis work was supported by the National Institutes of Health grants R01GM070795 and R01GM059138 to J-KZ.
dc.publisherSpringer Nature
dc.subjectDNA demethylation
dc.subjectDNA methylation
dc.subjecthistone modifications
dc.subjectRNA
dc.titleRegulation and function of DNA methylation in plants and animals
dc.typeArticle
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalCell Research
dc.identifier.pmcidPMC3152208
dc.contributor.institutionNational Institute of Biological Sciences, Beijing 102206, China
dc.contributor.institutionDevelopmental and Molecular Pathways, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, United States
dc.contributor.institutionHorticulture and Landscape Architecture Department, Purdue University, West Lafayette, IN 47907, United States
kaust.personZhu, Jian-Kang


This item appears in the following Collection(s)

Show simple item record