Plant transducers of the endoplasmic reticulum unfolded protein response
Type
ArticleAuthors
Iwata, YujiKoizumi, Nozomu
KAUST Department
Biological and Environmental Science and Engineering (BESE) DivisionCenter for Desert Agriculture
Date
2012-12Permanent link to this record
http://hdl.handle.net/10754/566016
Metadata
Show full item recordAbstract
The unfolded protein response (UPR) activates a set of genes to overcome accumulation of unfolded proteins in the endoplasmic reticulum (ER), a condition termed ER stress, and constitutes an essential part of ER protein quality control that ensures efficient maturation of secretory and membrane proteins in eukaryotes. Recent studies on Arabidopsis and rice identified the signaling pathway in which the ER membrane-localized ribonuclease IRE1 (inositol-requiring enzyme 1) catalyzes unconventional cytoplasmic splicing of mRNA, thereby producing the active transcription factor Arabidopsis bZIP60 (basic leucine zipper 60) and its ortholog in rice. Here we review recent findings identifying the molecular components of the plant UPR, including IRE1/bZIP60 and the membrane-bound transcription factors bZIP17 and bZIP28, and implicating its importance in several physiological phenomena such as pathogen response. © 2012 Elsevier Ltd.Citation
Iwata, Y., & Koizumi, N. (2012). Plant transducers of the endoplasmic reticulum unfolded protein response. Trends in Plant Science, 17(12), 720–727. doi:10.1016/j.tplants.2012.06.014Publisher
Elsevier BVJournal
Trends in Plant SciencePubMed ID
22796463ae974a485f413a2113503eed53cd6c53
10.1016/j.tplants.2012.06.014
Scopus Count
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