AuthorsFedoroff, Nina V.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Desert Agriculture Initiative
Permanent link to this recordhttp://hdl.handle.net/10754/565994
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AbstractIn 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring.
PubMed Central IDPMC3528499
- Barbara McClintock and the discovery of jumping genes.
- Authors: Ravindran S
- Issue date: 2012 Dec 11
- McClintock's controlling elements: the full story.
- Authors: Jones RN
- Issue date: 2005
- Barbara McClintock's Final Years as Nobelist and Mentor: A Memoir.
- Authors: Chomet P, Martienssen R
- Issue date: 2017 Sep 7
- Transposable elements as catalysts for chromosome rearrangements.
- Authors: Zhang J, Yu C, Krishnaswamy L, Peterson T
- Issue date: 2011
- Restructuring the genome in response to adaptive challenge: McClintock's bold conjecture revisited.
- Authors: Jorgensen RA
- Issue date: 2004