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dc.contributor.authorWoo, Yong
dc.contributor.authorAnsari, Hifzur Rahman
dc.contributor.authorOtto, Thomas D.
dc.contributor.authorLinger, Christen M K
dc.contributor.authorOlisko, Martin K.
dc.contributor.authorMichálek, Jan
dc.contributor.authorSaxena, Alka
dc.contributor.authorShanmugam, Dhanasekaran
dc.contributor.authorTayyrov, Annageldi
dc.contributor.authorVeluchamy, Alaguraj
dc.contributor.authorAli, Shahjahan
dc.contributor.authorBernal, Axel
dc.contributor.authorDel Campo, Javier
dc.contributor.authorCihlář, Jaromír
dc.contributor.authorFlegontov, Pavel
dc.contributor.authorGornik, Sebastian G.
dc.contributor.authorHajdušková, Eva
dc.contributor.authorHorák, Aleš
dc.contributor.authorJanouškovec, Jan
dc.contributor.authorKatris, Nicholas J.
dc.contributor.authorMast, Fred D.
dc.contributor.authorMiranda-Saavedra, Diego
dc.contributor.authorMourier, Tobias
dc.contributor.authorNaeem, Raeece
dc.contributor.authorNair, Mridul
dc.contributor.authorPanigrahi, Aswini Kumar
dc.contributor.authorRawlings, Neil D.
dc.contributor.authorPadron Regalado, Eriko
dc.contributor.authorRamaprasad, Abhinay
dc.contributor.authorSamad, Nadira
dc.contributor.authorTomčala, Aleš
dc.contributor.authorWilkes, Jon
dc.contributor.authorNeafsey, Daniel E.
dc.contributor.authorDoerig, Christian
dc.contributor.authorBowler, Chris
dc.contributor.authorKeeling, Patrick J.
dc.contributor.authorRoos, David S.
dc.contributor.authorDacks, Joel B.
dc.contributor.authorTempleton, Thomas J.
dc.contributor.authorWaller, Ross F.
dc.contributor.authorLukeš, Julius
dc.contributor.authorOborník, Miroslav
dc.contributor.authorPain, Arnab
dc.date.accessioned2015-08-12T08:57:03Z
dc.date.available2015-08-12T08:57:03Z
dc.date.issued2015-07-14
dc.identifier.citationWoo, Y. H., Ansari, H., Otto, T. D., Klinger, C. M., Kolisko, M., Michálek, J., … Pain, A. (2015). Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites. eLife, 4. doi:10.7554/elife.06974
dc.identifier.issn2050-084X
dc.identifier.pmid26175406
dc.identifier.doi10.7554/eLife.06974
dc.identifier.urihttp://hdl.handle.net/10754/565962
dc.description.abstractThe eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis, free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes, such as extracellular proteins, components of a motility apparatus, and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions, Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus, supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. © Woo et al.
dc.publishereLife Sciences Publications, Ltd
dc.relation.urlhttp://europepmc.org/articles/pmc4501334?pdf=render
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rightsThis file is an open access version redistributed from: http://europepmc.org/articles/pmc4501334?pdf=render
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleChromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Core Lab
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentPathogen Genomics Laboratory
dc.contributor.departmentCore Labs
dc.identifier.journaleLife
dc.eprint.versionPublisher's Version/PDF
kaust.personAnsari, Hifzur Rahman
kaust.personAli, Shahjahan
kaust.personNaeem, Raeece
kaust.personNair, Mridul
kaust.personPanigrahi, Aswini Kumar
kaust.personRamaprasad, Abhinay
kaust.personPain, Arnab
kaust.personWoo, Yong
kaust.personSaxena, Alka
kaust.personTayyrov, Annageldi
kaust.personPadron Regalado, Eriko
refterms.dateFOA2020-08-24T13:01:32Z


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This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Except where otherwise noted, this item's license is described as This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.